HNRNPU, heterogeneous nuclear ribonucleoprotein U

HNRNPU, heterogeneous nuclear ribonucleoprotein U

• This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The encoded protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in this gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of this gene has been identified on chromosome 14. [provided by RefSeq, Jun 2017]

• Gene Synonyms (heterogeneous nuclear ribonucleoprotein U, HNRNPU antisense RNA 1, heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A), nuclear p120 ribonucleoprotein, p120 nuclear protein, EIEE54, GRIP120, HNRNPU-AS1, HNRPU, SAF-A, SAFA, U21.1, hnRNP U, pp120,)
• NCBI Gene ID: 3192
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96BA7
  UNIPROT ID#>>Q00839
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

heterogeneous nuclear ribonucleoprotein U interacts with:

• 2'-5'-oligoadenylate synthetase like
  5'-3' exoribonuclease 2
  AAR2 splicing factor
  activator of HSP90 ATPase activity 1
  Aly/REF export factor
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis and caspase activation inhibitor
  apoptosis antagonizing transcription factor
  apoptosis inhibitor 5
  ariadne RBR E3 ubiquitin protein ligase 2
  armadillo repeat containing 12
  ataxin 3
  aurora kinase A
  aurora kinase B
  BAG cochaperone 3
  basic transcription factor 3 like 4
  beta-transducin repeat containing E3 ubiquitin protein ligase
  biogenesis of ribosomes BRX1
  BRCA2 and CDKN1A interacting protein
  bromodomain adjacent to zinc finger domain 1B
  bromodomain containing 7
  cap methyltransferase 1
  CCAAT enhancer binding protein zeta
  CCCTC-binding factor
  CCCTC-binding factor
  CDKN2A interacting protein
  cell division cycle associated 4
  centromere protein V
  centromere protein W
  centrosomal protein 250
  centrosomal protein 57
  centrosomal protein 70
  centrosomal protein 76
  cereblon
  checkpoint kinase 2
  chromobox 8
  chromosome 12 open reading frame 43
  chromosome 18 open reading frame 21
  chromosome 19 open reading frame 53
  coiled-coil domain containing 137
  coiled-coil domain containing 8
  coiled-coil domain containing 86
  COP9 signalosome subunit 5
  cullin 1
  cullin 2
  cullin 3
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cyclin-dependent kinase 1
  DEAD-box helicase 18
  DEAD-box helicase 24
  DEAD-box helicase 27
  DEAD-box helicase 31
  DEAD-box helicase 47
  DEAD-box helicase 54
  DEAH-box helicase 33
  death associated protein 3
  decapping enzyme, scavenger
  defective in cullin neddylation 1 domain containing 1
  developmental pluripotency-associated 3
  DExD-box helicase 21
  DExD-box helicase 50
  DExH-box helicase 29
  DExH-box helicase 30
  DGCR8 microprocessor complex subunit
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  DNA topoisomerase II alpha
  DOT1 like histone lysine methyltransferase
  dual specificity tyrosine phosphorylation regulated kinase 2
  EBNA1 binding protein 2
  elongation factor for RNA polymerase II
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  ESF1 nucleolar pre-rRNA processing protein homolog
  essential meiotic structure-specific endonuclease 1
  eukaryotic elongation factor, selenocysteine-tRNA specific
  eukaryotic translation initiation factor 2B subunit beta
  eukaryotic translation initiation factor 2B subunit delta
  eukaryotic translation initiation factor 2B subunit gamma
  eukaryotic translation initiation factor 3 subunit C
  eukaryotic translation initiation factor 3 subunit D
  eukaryotic translation initiation factor 3 subunit J
  eukaryotic translation initiation factor 3, subunit A
  eukaryotic translation initiation factor 3, subunit E
  eukaryotic translation initiation factor 4A3
  eukaryotic translation initiation factor 6
  exosome component 10
  exosome component 4
  expressed sequence AI837181
  extra spindle pole bodies like 1, separase
  family with sequence similarity 120A
  family with sequence similarity 120C
  Fas associated factor 1
  F-box and leucine rich repeat protein 6
  F-box and WD repeat domain containing 11
  F-box and WD-40 domain protein 11
  F-box protein 7
  FCF1 rRNA-processing protein
  focadhesin
  FtsJ RNA 2'-O-methyltransferase 3
  G protein nucleolar 2
  G protein nucleolar 3
  G protein nucleolar 3 like
  G3BP stress granule assembly factor 1
  galectin 3 binding protein
  gigaxonin
  glyoxylate reductase 1 homolog
  GPN-loop GTPase 1
  growth arrest specific 7
  GTP binding protein 2
  GTP binding protein 4
  H1.10 linker histone
  H2B clustered histone 13
  H4 clustered histone 1
  HAUS augmin like complex subunit 2
  heat shock protein 90 beta family member 1
  heat shock protein family A (Hsp70) member 5
  heat shock protein family A (Hsp70) member 9
  heat shock protein family B (small) member 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 5
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein R
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 4
  histone deacetylase 6
  hydroxysteroid 17-beta dehydrogenase 4
  IK cytokine
  immunoglobulin mu DNA binding protein 2
  immunoglobulin superfamily member 8
  influenza virus NS1A binding protein
  inhibitor of nuclear factor kappa B kinase subunit beta
  inositol polyphosphate phosphatase like 1
  insulin like growth factor 2 mRNA binding protein 1
  insulin like growth factor 2 mRNA binding protein 3
  integrin alpha FG-GAP repeat containing 1
  integrin subunit alpha 4
  integrin subunit alpha 5
  integrin subunit beta 4
  intercellular adhesion molecule 1
  interferon alpha and beta receptor subunit 1
  interferon gamma inducible protein 16
  interferon induced protein with tetratricopeptide repeats 3
  interleukin 7 receptor
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  ISG15 ubiquitin like modifier
  keratin 14
  keratin 17
  keratin 18
  keratin 3
  KIAA2013
  KRAB-A domain containing 2
  KRI1 homolog
  KRR1 small subunit processome component homolog
  La ribonucleoprotein 1, translational regulator
  La ribonucleoprotein 7, transcriptional regulator
  lamin A/C
  lamin B receptor
  lectin, mannose binding 1
  leucine rich repeat containing G protein-coupled receptor 4
  LIM zinc finger domain containing 1
  LSM14A mRNA processing body assembly factor
  LTV1 ribosome biogenesis factor
  LUC7 like 3 pre-mRNA splicing factor
  Ly1 antibody reactive
  lysine acetyltransferase 2B
  lysine demethylase 4B
  lysosomal associated membrane protein 2
  lysosomal protein transmembrane 4 alpha
  MAGE family member A3
  MAGE family member D2
  mago homolog, exon junction complex subunit
  matrin 3
  MDM2 proto-oncogene
  mediator of DNA damage checkpoint 1
  metal regulatory transcription factor 1
  methionyl aminopeptidase 1
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 3
  microtubule associated protein 1 light chain 3 alpha
  minichromosome maintenance complex component 2
  minichromosome maintenance complex component 5
  mitochondrial carrier 1
  mitochondrial carrier 2
  mitochondrial ribosomal protein L10
  mitochondrial ribosomal protein L13
  mitochondrial ribosomal protein L23
  mitochondrial ribosomal protein L27
  mitochondrial ribosomal protein L38
  mitochondrial ribosomal protein L42
  mitochondrial ribosomal protein L44
  mitochondrial ribosomal protein L46
  mitochondrial ribosomal protein L48
  mitochondrial ribosomal protein L50
  mitochondrial ribosomal protein L51
  mitochondrial ribosomal protein L52
  mitochondrial ribosomal protein L58
  mitochondrial ribosomal protein S14
  mitochondrial ribosomal protein S15
  mitochondrial ribosomal protein S16
  mitochondrial ribosomal protein S2
  mitochondrial ribosomal protein S25
  mitochondrial ribosomal protein S27
  mitochondrial ribosomal protein S28
  mitochondrial ribosomal protein S33
  mitochondrial ribosomal protein S34
  mitochondrial ribosomal protein S35
  mitochondrial ribosomal protein S9
  mono-ADP ribosylhydrolase 1
  mortality factor 4 like 1
  mortality factor 4 like 2
  MRE11 homolog, double strand break repair nuclease
  MRG domain binding protein
  MRT4 homolog, ribosome maturation factor
  MUS81 structure-specific endonuclease subunit
  MYB binding protein 1a
  MYC associated factor X
  MYC proto-oncogene, bHLH transcription factor
  myosin heavy chain 9
  myristoylated alanine rich protein kinase C substrate
  N-acetyltransferase 10
  NDC80 kinetochore complex component
  necdin, MAGE family member
  NEDD1 gamma-tubulin ring complex targeting factor
  NEDD4 E3 ubiquitin protein ligase
  NEDD8 ubiquitin like modifier
  negative elongation factor complex member B
  neurobeachin like 1
  neurotrophic receptor tyrosine kinase 1
  NFKB inhibitor alpha
  NFKB repressing factor
  nicastrin
  N-myc downstream regulated 1
  N-myristoyltransferase 1
  NOC2 like nucleolar associated transcriptional repressor
  NOC3 like DNA replication regulator
  non-POU domain containing octamer binding
  NOP2 nucleolar protein
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  nuclear factor I A
  nuclear receptor binding SET domain protein 2
  nuclear receptor subfamily 2 group C member 2
  nuclear transcription factor, X-box binding 1
  nuclear VCP like
  nucleolar pre-rRNA processing protein NIP7
  nucleolar protein 6
  nucleolin
  nucleolus and neural progenitor protein
  nucleophosmin 1
  nucleophosmin/nucleoplasmin 3
  obscurin like cytoskeletal adaptor 1
  palmitoyl-protein thioesterase 1
  parkin RBR E3 ubiquitin protein ligase
  partner of NOB1 homolog
  pentatricopeptide repeat domain 1
  peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  peptidylprolyl isomerase E
  peripherin
  PHD finger protein 14
  PHD finger protein 6
  PHD finger protein 8
  phosphatase and tensin homolog
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  PML nuclear body scaffold
  POC1 centriolar protein B
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  poly(A) specific ribonuclease subunit PAN2
  poly(rC) binding protein 1
  polynucleotide kinase 3'-phosphatase
  polypyrimidine tract binding protein 1
  POP1 homolog, ribonuclease P/MRP subunit
  POU class 3 homeobox 4
  pre-mRNA processing factor 4
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 8
  progesterone receptor membrane component 1
  programmed cell death 11
  programmed cell death 6
  prohibitin
  proline rich 3
  proteasome 26S subunit, non-ATPase 6
  protein arginine methyltransferase 1
  protein arginine methyltransferase 8
  protein kinase N3
  protein phosphatase 4 regulatory subunit 3B
  protein tyrosine phosphatase non-receptor type 1
  protein tyrosine phosphatase non-receptor type 11
  protocadherin 7
  protocadherin alpha 2
  PTEN induced kinase 1
  pumilio RNA binding family member 3
  pyruvate dehydrogenase E1 subunit alpha 2
  RAB2A, member RAS oncogene family
  RAD21 cohesin complex component
  RALY heterogeneous nuclear ribonucleoprotein
  RCC1 like
  RE1 silencing transcription factor
  RecQ like helicase 4
  RecQ protein-like 4
  replication factor C subunit 1
  replication factor C subunit 2
  replication factor C subunit 3
  replication factor C subunit 4
  replication factor C subunit 5
  replication protein A1
  replication protein A2
  replication protein A3
  retinoic acid receptor alpha
  REX4 homolog, 3'-5' exonuclease
  ribonuclease P/MRP subunit p25 like
  ribonuclease P/MRP subunit p38
  ribophorin I
  ribosomal L1 domain containing 1
  ribosomal oxygenase 1
  ribosomal oxygenase 2
  ribosomal protein L10
  ribosomal protein L10 like
  ribosomal protein L10a
  ribosomal protein L11
  ribosomal protein L12
  ribosomal protein L13
  ribosomal protein L13a
  ribosomal protein L15
  ribosomal protein L17
  ribosomal protein L18
  ribosomal protein L18a
  ribosomal protein L19
  ribosomal protein L21
  ribosomal protein L22
  ribosomal protein L23
  ribosomal protein L23a
  ribosomal protein L24
  ribosomal protein L27
  ribosomal protein L27a
  ribosomal protein L28
  ribosomal protein L3
  ribosomal protein L30
  ribosomal protein L32
  ribosomal protein L35
  ribosomal protein L35
  ribosomal protein L36
  ribosomal protein L36a
  ribosomal protein L4
  ribosomal protein L5
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein L7a
  ribosomal protein L8
  ribosomal protein L9
  ribosomal protein lateral stalk subunit P0
  ribosomal protein lateral stalk subunit P1
  ribosomal protein lateral stalk subunit P2
  ribosomal protein S10
  ribosomal protein S11
  ribosomal protein S12
  ribosomal protein S13
  ribosomal protein S14
  ribosomal protein S15
  ribosomal protein S15a
  ribosomal protein S16
  ribosomal protein S17
  ribosomal protein S18
  ribosomal protein S19
  ribosomal protein S2
  ribosomal protein S21
  ribosomal protein S23
  ribosomal protein S24
  ribosomal protein S25
  ribosomal protein S26
  ribosomal protein S27
  ribosomal protein S29
  ribosomal protein S3
  ribosomal protein S3A
  ribosomal protein S4 X-linked
  ribosomal protein S5
  ribosomal protein S6
  ribosomal protein S6 kinase B2
  ribosomal protein S7
  ribosomal protein S8
  ribosomal protein S9
  ribosomal protein SA
  ribosomal RNA processing 12 homolog
  ribosomal RNA processing 15 homolog
  ribosomal RNA processing 1B
  ribosomal RNA processing 7 homolog A
  ribosome binding protein 1
  ribosome biogenesis regulator 1 homolog
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 146
  ring finger protein 169
  ring finger protein 2
  ring finger protein 31
  ring finger protein 4
  ring-box 1
  RIO kinase 1
  RIO kinase 2
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 28
  RNA binding motif protein 34
  RNA binding motif protein 39
  RNA binding protein with serine rich domain 1
  RNA binding protein, mRNA processing factor 2
  RNA polymerase II subunit A
  RNA polymerase II subunit J
  RNA transcription, translation and transport factor
  RuvB like AAA ATPase 2
  S1 RNA binding domain 1
  S100 calcium binding protein A9
  scaffold attachment factor B
  SEM1 26S proteasome complex subunit
  septin 2
  serine and arginine rich splicing factor 1
  serine and arginine rich splicing factor 11
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 7
  serine/arginine repetitive matrix 2
  SERPINE1 mRNA binding protein 1
  SHC adaptor protein 1
  signal recognition particle 72
  signal recognition particle 72
  Sin3A associated protein 18
  single stranded DNA binding protein 1
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein 13
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein polypeptide A
  small nuclear ribonucleoprotein polypeptide A'
  small nuclear ribonucleoprotein U1 subunit 70
  small nuclear ribonucleoprotein U5 subunit 200
  SMU1 DNA replication regulator and spliceosomal factor
  snail family transcriptional repressor 1
  SNW domain containing 1
  solute carrier family 25 member 17
  solute carrier family 25 member 32
  solute carrier family 7 member 5
  spermatogenesis associated serine rich 2
  spermatogenesis associated serine rich 2 like
  spindle apparatus coiled-coil protein 1
  spleen associated tyrosine kinase
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor 3a subunit 1
  splicing factor 3a subunit 2
  splicing regulatory glutamic acid and lysine rich protein 1
  SPT16 homolog, facilitates chromatin remodeling subunit
  squamous cell carcinoma antigen recognized by T cells 3
  SRY-box transcription factor 2
  staphylococcal nuclease and tudor domain containing 1
  staufen double-stranded RNA binding protein 1
  staufen double-stranded RNA binding protein 2
  sterile alpha motif domain containing 1
  surfeit 6
  survival of motor neuron 2, centromeric
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  TAR DNA binding protein
  TATA-box binding protein associated factor 15
  tetratricopeptide repeat domain 37
  THAP domain containing 11
  thioredoxin domain containing 16
  thioredoxin related transmembrane protein 2
  thymopoietin
  thyroid hormone receptor associated protein 3
  thyroid hormone receptor interactor 10
  thyroid hormone receptor interactor 4
  transcription elongation regulator 1
  transcription factor CP2
  transcriptional adaptor 1
  transducin beta like 3
  transformer 2 alpha homolog
  transformer 2 beta homolog
  transforming growth factor beta 1
  translocated promoter region, nuclear basket protein
  transmembrane protein 41B
  tripartite motif containing 25
  tripartite motif containing 28
  tripartite motif containing 29
  tripartite motif containing 55
  tripartite motif-containing 69
  tRNA methyltransferase 1 like
  trophoblast glycoprotein
  TruB pseudouridine synthase family member 2
  TSR1 ribosome maturation factor
  tubulin gamma 1
  tubulin gamma complex associated protein 3
  tubulin gamma complex associated protein 4
  tumor necrosis factor
  tumor protein D52
  tumor protein p53
  U2 small nuclear RNA auxiliary factor 1
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  ubiquitin A-52 residue ribosomal protein fusion product 1
  ubiquitin associated and SH3 domain containing B
  ubiquitin C
  ubiquitin conjugating enzyme E2 I
  ubiquitin like 4A
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 36
  ubiquitin specific peptidase 39
  UBX domain protein 6
  unk zinc finger
  UPF1 RNA helicase and ATPase
  upstream binding transcription factor
  UTP14A small subunit processome component
  UTP18 small subunit processome component
  UTP23 small subunit processome component
  vascular cell adhesion molecule 1
  vir like m6A methyltransferase associated
  vitronectin
  voltage dependent anion channel 2
  von Hippel-Lindau tumor suppressor
  VRK serine/threonine kinase 1
  VRK serine/threonine kinase 3
  WD repeat containing antisense to TP53
  WD repeat domain 18
  WD repeat domain 3
  WD repeat domain 36
  WT1 associated protein
  WW domain binding protein 4
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  Y box protein 1
  Y-box binding protein 1
  Y-box binding protein 3
  Yes1 associated transcriptional regulator
  YTH domain containing 2
  zinc finger and BTB domain containing 7A
  zinc finger CCCH-type containing 18
  zinc finger FYVE-type containing 21
  zinc finger protein 622
  zinc finger protein 689

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.