SAP18, Sin3A associated protein 18

SAP18, Sin3A associated protein 18

• Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]

• Gene Synonyms (2HOR0202, SAP18P, histone deacetylase complex subunit SAP18, 18 kDa Sin3-associated polypeptide, Sin3A-associated protein, 18kDa, cell growth inhibiting protein 38, cell growth-inhibiting gene 38 protein, epididymis secretory sperm binding protein, histone deacetlyase complex subunit SAP18, sin3-associated polypeptide, 18 kDa, sin3-associated polypeptide, p18,)
• NCBI Gene ID: 10284
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00422
  UNIPROT ID#>>X6RAL5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Sin3A associated protein 18 interacts with:

• acidic residue methyltransferase 1
  activity dependent neuroprotector homeobox
  anaphase promoting complex subunit 13
  anoctamin 7
  apoptotic chromatin condensation inducer 1
  ATP synthase membrane subunit g
  coiled-coil domain containing 22
  coiled-coil domain containing 9
  DEF6 guanine nucleotide exchange factor
  EBNA1 binding protein 2
  erythrocyte membrane protein band 4.1 like 3
  eukaryotic translation initiation factor 2 subunit gamma B
  IKAROS family zinc finger 1
  inhibitor of CDK, cyclin A1 interacting protein 1
  kinesin family binding protein
  lectin, galactoside-binding, soluble, 3 binding protein
  leucine zipper protein 4
  listerin E3 ubiquitin protein ligase 1
  nicastrin
  ninein like
  N-terminal glutamine amidase 1
  nucleolar protein 12
  oxysterol binding protein like 10
  Parkinsonism associated deglycase
  PC4 and SFRS1 interacting protein 1
  phosphoglycerate dehydrogenase
  polycomb group ring finger 1
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 6
  RAD18 E3 ubiquitin protein ligase
  ribonuclease H2 subunit B
  RNA binding motif protein 14
  RNA binding protein with serine rich domain 1
  serine and arginine rich splicing factor 10
  serrate, RNA effector molecule
  SIN3 transcription regulator family member A
  Sin3A associated protein 18
  SMU1 DNA replication regulator and spliceosomal factor
  solute carrier family 35 member A1
  sonic hedgehog
  spindle and kinetochore associated complex subunit 3
  SPT16 homolog, facilitates chromatin remodeling subunit
  SUFU negative regulator of hedgehog signaling
  SUFU negative regulator of hedgehog signaling
  SUZ12 polycomb repressive complex 2 subunit
  TNFAIP3 interacting protein 2
  transcriptional adaptor 3
  transcriptional regulator, SIN3A (yeast)
  transformer 2 alpha homolog
  tripartite motif containing 55
  tripartite motif containing 56
  tubulin gamma complex associated protein 3
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin specific peptidase 37
  WD repeat domain 18
  YTH domain containing 1
  zinc finger MYND-type containing 11

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.