IL7R, interleukin 7 receptor

IL7R, interleukin 7 receptor

• The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015]

• Gene Synonyms (interleukin-7 receptor subunit alpha, CD127 antigen, IL-7 receptor subunit alpha, IL-7R subunit alpha, interleukin 7 receptor alpha chain, interleukin 7 receptor isoform H5-6, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA,)
• NCBI Gene ID: 3575
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P16871
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 7 receptor interacts with:

• Aly/REF export factor
  angiotensin II receptor associated protein
  apolipoprotein L3
  cleavage and polyadenylation specific factor 1
  cytokine receptor like factor 2
  DEAH-box helicase 36
  DExD-box helicase 21
  DExD-box helicase 39B
  DNA topoisomerase I
  EMG1 N1-specific pseudouridine methyltransferase
  eukaryotic translation initiation factor 2 alpha kinase 2
  G3BP stress granule assembly factor 1
  H1.10 linker histone
  H2B clustered histone 21
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U like 1
  heterogeneous nuclear ribonucleoprotein U like 2
  interleukin enhancer binding factor 2
  interleukin enhancer binding factor 3
  Janus kinase 1
  Janus kinase 3
  KIT proto-oncogene, receptor tyrosine kinase
  LYN proto-oncogene, Src family tyrosine kinase
  mal, T cell differentiation protein like
  microtubule associated protein 4
  non-POU domain containing octamer binding
  nucleolin
  phosphoinositide-3-kinase regulatory subunit 1
  poly(A) binding protein cytoplasmic 1
  poly(A) binding protein cytoplasmic 4
  poly(A) binding protein nuclear 1
  polypyrimidine tract binding protein 1
  prothymosin alpha
  purine rich element binding protein A
  purine rich element binding protein B
  QKI, KH domain containing RNA binding
  RAD21 cohesin complex component
  Ras related GTP binding A
  receptor for activated C kinase 1
  ribosomal L1 domain containing 1
  ribosomal protein L15
  ribosomal protein L18
  ribosomal protein L22
  ribosomal protein L29
  ribosomal protein L30
  ribosomal protein L31
  ribosomal protein L6
  ribosomal protein L7
  ribosomal protein L8
  ribosomal protein S20
  ribosomal protein S3
  ribosomal protein SA
  RNA binding motif protein 3
  RNA binding motif protein X-linked
  scaffold attachment factor B
  serine and arginine rich splicing factor 3
  serine and arginine rich splicing factor 9
  signal recognition particle 14
  signal recognition particle 9
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  small nuclear ribonucleoprotein D1 polypeptide
  small nuclear ribonucleoprotein D2 polypeptide
  small nuclear ribonucleoprotein D3 polypeptide
  small nuclear ribonucleoprotein polypeptide A
  small nuclear ribonucleoprotein polypeptide E
  small nuclear ribonucleoprotein polypeptide F
  small nuclear ribonucleoprotein polypeptide G
  small nuclear ribonucleoprotein polypeptides B and B1
  small nuclear ribonucleoprotein U1 subunit 70
  small RNA binding exonuclease protection factor La
  splicing factor 1
  splicing factor 3a subunit 1
  splicing factor 3b subunit 1
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 2
  synaptotagmin binding cytoplasmic RNA interacting protein
  syndecan 4
  target of EGR1, exonuclease
  thymic stromal lymphopoietin
  transmembrane protein 120B
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  U2 small nuclear RNA auxiliary factor 1
  U2 small nuclear RNA auxiliary factor 2
  Y-box binding protein 1
  Y-box binding protein 3
  zinc finger protein 787

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.