U2AF1, U2 small nuclear RNA auxiliary factor 1

U2AF1, U2 small nuclear RNA auxiliary factor 1

• This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

• Gene Synonyms (splicing factor U2AF 35 kDa subunit, U2 small nuclear RNA auxillary factor 1, U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit, U2 snRNP auxiliary factor small subunit, U2(RNU2) small nuclear RNA auxiliary factor binding protein, splicing factor U2AF 35kDa subunit, FP793, RN, RNU2AF1, U2AF35, U2AFBP,)
• NCBI Gene ID: 7307
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z780
  UNIPROT ID#>>Q01081
  UNIPROT ID#>>P0DN76
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

U2 small nuclear RNA auxiliary factor 1 interacts with:

• AAR2 splicing factor
  apoptotic chromatin condensation inducer 1
  BCAS2 pre-mRNA processing factor
  bromodomain containing 7
  calcium homeostasis endoplasmic reticulum protein
  carnosine N-methyltransferase 1
  cilia and flagella associated protein 20
  corepressor interacting with RBPJ, CIR1
  cullin 1
  cullin 3
  cullin 7
  cullin associated and neddylation dissociated 1
  DDB1 and CUL4 associated factor 1
  DEAD-box helicase 56
  DEAH-box helicase 38
  death inducer-obliterator 1
  decapping enzyme, scavenger
  developmental pluripotency-associated 3
  EF-hand domain containing 2
  elongation factor Tu GTP binding domain containing 2
  FRA10A associated CGG repeat 1
  FtsJ RNA 2'-O-methyltransferase 3
  G3BP stress granule assembly factor 1
  H2A clustered histone 4
  H4 clustered histone 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HEXIM P-TEFb complex subunit 1
  histone H4 transcription factor
  integrin alpha FG-GAP repeat containing 1
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  keratin 75
  La ribonucleoprotein 7, transcriptional regulator
  LUC7 like 2, pre-mRNA splicing factor
  methylphosphate capping enzyme
  NFKB activating protein
  nicastrin
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  nuclear RNA export factor 1
  obscurin like cytoskeletal adaptor 1
  PC4 and SFRS1 interacting protein 1
  phosphoglycerate dehydrogenase
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 38A
  pre-mRNA processing factor 4
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  proteasome activator subunit 3
  RecQ like helicase 4
  ribosomal RNA processing 7 homolog A
  ribosome biogenesis regulator 1 homolog
  RIO kinase 1
  RNA binding motif protein 10
  RNA binding motif protein 25
  RNA binding protein with serine rich domain 1
  serine/arginine repetitive matrix 2
  serine/arginine repetitive matrix 4
  Sin3A associated protein 18
  SMAD specific E3 ubiquitin protein ligase 1
  small nuclear ribonucleoprotein U11/U12 subunit 35
  SNW domain containing 1
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  splicing factor 3a subunit 1
  splicing factor 3a subunit 2
  splicing factor 3a subunit 3
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  splicing factor 3b subunit 3
  splicing factor 3b subunit 6
  SR-related CTD associated factor 11
  SRSF protein kinase 3
  SUZ12 polycomb repressive complex 2 subunit
  synaptotagmin binding cytoplasmic RNA interacting protein
  target of EGR1, exonuclease
  THO complex 6
  tripartite motif containing 28
  tubulin alpha 1b
  U2 small nuclear RNA auxiliary factor 1 like 4
  U2 small nuclear RNA auxiliary factor 2
  vascular endothelial growth factor A
  WW domain containing E3 ubiquitin protein ligase 2
  zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  zinc finger CCHC-type containing 10
  zinc finger CCHC-type containing 8
  zinc finger protein 417
  zinc finger protein 746
  zinc finger RANBP2-type containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.