EIF2AK2, eukaryotic translation initiation factor 2 alpha kinase 2

EIF2AK2, eukaryotic translation initiation factor 2 alpha kinase 2

• The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Gene Synonyms (interferon-induced, double-stranded RNA-activated protein kinase, P1/eIF-2A protein kinase, double stranded RNA activated protein kinase, eIF-2A protein kinase 2, interferon-inducible elF2alpha kinase, p68 kinase, protein kinase R, protein kinase, interferon-inducible double stranded RNA dependent, protein phosphatase 1, regulatory subunit 83, tyrosine-protein kinase EIF2AK2, EIF2AK1, LEUDEN, PKR, PPP1R83, PRKR,)
• NCBI Gene ID: 5610
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IW76
  UNIPROT ID#>>P19525
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation initiation factor 2 alpha kinase 2 interacts with:

• 5'-3' exoribonuclease 2
  ATPase H+ transporting V1 subunit F
  bromodomain containing 7
  cell division cycle 37, HSP90 cochaperone
  cell division cycle associated 5
  charged multivesicular body protein 4B
  coiled-coil domain containing 124
  cullin 3
  cullin associated and neddylation dissociated 1
  developmental pluripotency-associated 3
  DExH-box helicase 30
  DExH-box helicase 58
  dicer 1, ribonuclease III
  DNA topoisomerase I
  DnaJ heat shock protein family (Hsp40) member C3
  drebrin like
  EBNA1 binding protein 2
  elongation factor Tu GTP binding domain containing 2
  enhancer of mRNA decapping 4
  eukaryotic translation initiation factor 2 alpha kinase 2
  eukaryotic translation initiation factor 2A
  FtsJ RNA 2'-O-methyltransferase 3
  G protein nucleolar 3
  GTP binding protein 4
  H2A clustered histone 20
  H2A clustered histone 4
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  heterogeneous nuclear ribonucleoprotein C like 1
  insulin like growth factor 2 mRNA binding protein 2
  insulin like growth factor 2 mRNA binding protein 3
  IQ motif containing F1
  ISG15 ubiquitin like modifier
  Janus kinase 2
  kinesin family member 18B
  La ribonucleoprotein 7, transcriptional regulator
  Ly1 antibody reactive
  methionyl aminopeptidase 2
  mitochondrial antiviral signaling protein
  mitogen-activated protein kinase kinase kinase 7
  mitotic deacetylase associated SANT domain protein
  mono-ADP ribosylhydrolase 1
  NHL repeat containing 2
  NOC3 like DNA replication regulator
  NOP53 ribosome biogenesis factor
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  phenylalanyl-tRNA synthetase subunit beta
  phosphatase and tensin homolog
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 4
  potassium channel tetramerization domain containing 17
  PRKR interacting protein 1
  prostaglandin E synthase 3
  protein activator of interferon induced protein kinase EIF2AK2
  purine rich element binding protein A
  Rac family small GTPase 1
  RecQ like helicase 4
  ribosomal protein L10
  ribosomal protein L6
  ribosomal protein lateral stalk subunit P0
  ribosomal protein S2
  ribosomal protein S3A
  ribosome binding protein 1
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  small nuclear ribonucleoprotein U1 subunit 70
  small RNA binding exonuclease protection factor La
  small ubiquitin like modifier 1
  small ubiquitin like modifier 2
  spermatid perinuclear RNA binding protein
  staufen double-stranded RNA binding protein 1
  staufen double-stranded RNA binding protein 2
  TARBP2 subunit of RISC loading complex
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  THAP domain containing 12
  thyroid hormone receptor interactor 4
  TIR domain containing adaptor protein
  TNF receptor associated factor 2
  TNF receptor associated factor 5
  TNF receptor associated factor 6
  toll interacting protein
  tripartite motif containing 28
  tumor protein p53
  tumor protein, translationally-controlled 1
  tyrosine kinase 2
  ubiquitin conjugating enzyme E2 I
  zinc finger protein 346

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.