RFC1, replication factor C subunit 1

RFC1, replication factor C subunit 1

• This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]

• Gene Synonyms (replication factor C subunit 1, A1 140 kDa subunit, DNA-binding protein PO-GA, MHC binding factor, beta, RF-C 140 kDa subunit, activator 1 140 kDa subunit, activator 1 large subunit, activator 1 subunit 1, replication factor C (activator 1) 1, 145kDa, replication factor C 140 kDa subunit, replication factor C large subunit, replication factor C1, A1, CANVAS, MHCBFB, PO-GA, RECC1, RFC, RFC140,)
• NCBI Gene ID: 5981
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P35251
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

replication factor C subunit 1 interacts with:

• aurora kinase A interacting protein 1
  bromodomain and WD repeat domain containing 3
  bromodomain containing 4
  bromodomain containing 7
  cell division cycle 45
  checkpoint kinase 2
  chromosome transmission fidelity factor 18
  elongation factor Tu GTP binding domain containing 2
  ER membrane protein complex subunit 2
  eukaryotic translation initiation factor 3, subunit I
  glutamate rich WD repeat containing 1
  glyoxylate reductase 1 homolog
  H2A clustered histone 4
  H2B clustered histone 8
  H3 clustered histone 1
  H4 clustered histone 1
  inhibitor of Bruton tyrosine kinase
  ligand dependent nuclear receptor corepressor
  macroH2A.2 histone
  MUS81 structure-specific endonuclease subunit
  NK2 homeobox 1
  NOP56 ribonucleoprotein
  nuclear receptor subfamily 2 group C member 2
  nucleolar protein interacting with the FHA domain of MKI67
  obscurin like cytoskeletal adaptor 1
  PDS5 cohesin associated factor A
  pleckstrin homology domain containing A4
  potassium channel tetramerisation domain containing 5
  PR/SET domain 16
  proliferating cell nuclear antigen
  Rac GTPase activating protein 1
  RAD50 double strand break repair protein
  RecQ like helicase 4
  replication factor C subunit 1
  replication factor C subunit 2
  replication factor C subunit 3
  replication factor C subunit 4
  replication factor C subunit 5
  replication protein A1
  replication protein A2
  replication protein A3
  ribosomal protein L18a
  ribosomal protein L35
  ribosomal protein S6
  ribosomal RNA processing 8
  ribosome binding protein 1
  ring finger and CCCH-type domains 1
  RNA binding motif protein 14
  Sin3A associated protein 25
  single stranded DNA binding protein 3
  sirtuin 7
  small nuclear ribonucleoprotein U1 subunit 70
  SprT-like N-terminal domain
  SRY-box transcription factor 2
  structural maintenance of chromosomes 1A
  structural maintenance of chromosomes 2
  structural maintenance of chromosomes 4
  TEA domain transcription factor 2
  thrombospondin 3
  TRAF interacting protein
  transcription elongation factor A like 1
  tripartite motif containing 29
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin C
  vesicle associated membrane protein 5
  vir like m6A methyltransferase associated
  WD repeat domain 18
  WD repeat domain 76
  WW domain containing E3 ubiquitin protein ligase 2
  X-ray repair cross complementing 5
  zinc finger and BTB domain containing 7A
  zinc finger and SCAN domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.