MRE11, MRE11 homolog, double strand break repair nuclease

MRE11, MRE11 homolog, double strand break repair nuclease

• This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

• Gene Synonyms (ATLD, HNGS1, MRE11A, MRE11B, double-strand break repair protein MRE11, AT-like disease, DNA recombination and repair protein, MRE11 double strand break repair nuclease A, MRE11 homolog 1, MRE11 homolog A, double strand break repair nuclease, MRE11 homolog, double strand break repair nuclease A, MRE11 meiotic recombination 11 homolog A, MRE11 meiotic recombination 11-like protein A, double-strand break repair protein MRE11A, endo/exonuclease Mre11, meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A,)
• NCBI Gene ID: 4361
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q05D78
  UNIPROT ID#>>P49959
  UNIPROT ID#>>F8W7U8
  UNIPROT ID#>>A0A024R395
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MRE11 homolog, double strand break repair nuclease interacts with:

• axin interactor, dorsalization associated
  BRCA1 interacting protein C-terminal helicase 1
  cell division cycle 45
  centrosomal protein 43
  chromosome alignment maintaining phosphoprotein 1
  chymotrypsin like elastase 2B
  cilia and flagella associated protein 161
  cullin 7
  cytosolic iron-sulfur assembly component 1
  DNA cross-link repair 1B
  DNA cross-link repair 1C
  DNA polymerase alpha 1, catalytic subunit
  dual specificity phosphatase 10
  dynein light chain LC8-type 1
  dynein regulatory complex subunit 1
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  embryonic ectoderm development
  eukaryotic translation initiation factor 2B subunit beta
  eukaryotic translation initiation factor 2B subunit gamma
  exonuclease 3'-5' domain containing 2
  family with sequence similarity 219 member A
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 7
  forkhead box P1
  GINS complex subunit 1
  glutaminyl-tRNA synthetase 1
  golgi brefeldin A resistant guanine nucleotide exchange factor 1
  GRIP and coiled-coil domain containing 2
  H3 clustered histone 6
  H3.4 histone
  H4 clustered histone 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heterogeneous nuclear ribonucleoprotein M
  histone acetyltransferase 1
  histone deacetylase 6
  hook microtubule tethering protein 3
  insulin like growth factor 2 mRNA binding protein 3
  La ribonucleoprotein 7, transcriptional regulator
  LRR binding FLII interacting protein 1
  lysine acetyltransferase 5
  mediator of DNA damage checkpoint 1
  microtubule associated protein 7
  minichromosome maintenance 9 homologous recombination repair factor
  mitogen-activated protein kinase 8 interacting protein 2
  MRE11 homolog, double strand break repair nuclease
  mutS homolog 2
  MYC proto-oncogene, bHLH transcription factor
  Nanog homeobox
  negative elongation factor complex member B
  neurotrophic receptor tyrosine kinase 1
  nibrin
  NIMA related kinase 1
  NLR family pyrin domain containing 2
  N-myristoyltransferase 1
  nuclear factor of activated T cells 2
  nuclear receptor subfamily 2 group C member 2
  obscurin like cytoskeletal adaptor 1
  OFD1 centriole and centriolar satellite protein
  outer dense fiber of sperm tails 2
  patched 1
  PAX interacting protein 1
  pellino E3 ubiquitin protein ligase 1
  peroxisome proliferator activated receptor gamma
  pleckstrin homology domain containing A4
  poly(A) specific ribonuclease subunit PAN2
  polycomb group ring finger 1
  POU class 5 homeobox 1
  protein kinase, DNA-activated, catalytic subunit
  PTEN induced kinase 1
  RAB32, member RAS oncogene family
  RAD50 double strand break repair protein
  RB binding protein 4, chromatin remodeling factor
  RB binding protein 8, endonuclease
  RecQ like helicase 4
  RecQ like helicase 5
  regulator of G protein signaling 20
  replication factor C subunit 1
  replication factor C subunit 4
  replication protein A1
  replication protein A2
  replication protein A3
  ribosomal protein L26 like 1
  ribosomal protein L27
  ring finger protein 123
  ring finger protein 169
  ring finger protein 8
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA transcription, translation and transport factor
  secretogranin III
  semenogelin 2
  sirtuin 7
  SLX4 structure-specific endonuclease subunit
  small ubiquitin like modifier 2
  SNW domain containing 1
  speckle type BTB/POZ protein
  spectrin alpha, erythrocytic 1
  S-phase kinase associated protein 2
  staufen double-stranded RNA binding protein 1
  SUMO specific peptidase 3
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  telomeric repeat binding factor 2
  TERF1 interacting nuclear factor 2
  TERF2 interacting protein
  thioredoxin interacting protein
  thymopoietin
  transformation/transcription domain associated protein
  transforming acidic coiled-coil containing protein 3
  translocated promoter region, nuclear basket protein
  tripartite motif containing 28
  tripartite motif containing 29
  tubulin, gamma complex associated protein 6
  tumor protein p53
  tumor protein p53 binding protein 1
  tumor protein, translationally-controlled 1
  ubiquilin 2
  ubiquilin 4
  ubiquitin C
  ubiquitin conjugating enzyme E2 A
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 4
  ubiquitin specific peptidase 7
  Y-box binding protein 3
  zinc finger protein 365

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.