POU5F1, POU class 5 homeobox 1

POU5F1, POU class 5 homeobox 1

• This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

• Gene Synonyms (POU domain, class 5, transcription factor 1, POU class 5 homeobox 1 transcript variant OCT4B1, POU class 5 homeobox 1 transcript variant OCT4B2, POU class 5 homeobox 1 transcript variant OCT4B3, POU class 5 homeobox 1 transcript variant OCT4B4, POU class 5 homeobox 1 transcript variant OCT4B5, POU class 5 homeobox 1 transcript variant OCT4B6, POU classV homeobox 1 variant 2, POU domain transcription factor OCT4, POU-type homeodomain-containing DNA-binding protein, octamer-binding protein 3, octamer-binding protein 4, octamer-binding transcription factor 3, OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4,)
• NCBI Gene ID: 5460
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D2IYK3
  UNIPROT ID#>>M1S623
  UNIPROT ID#>>F2Z381
  UNIPROT ID#>>Q01860
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

POU class 5 homeobox 1 interacts with:

• 5'-nucleotidase domain containing 2
  acyl-CoA thioesterase 9
  adaptor related protein complex 3 subunit delta 1
  anaphase promoting complex subunit 4
  angel homolog 2
  anterior gradient 2, protein disulphide isomerase family member
  apoptosis inhibitor 5
  armadillo repeat containing X-linked 1
  AT-rich interaction domain 1B
  autophagy related 101
  BAG cochaperone 2
  BAG cochaperone 6
  CAP-Gly domain containing linker protein 1
  cell cycle and apoptosis regulator 2
  cereblon
  chromobox 2
  chromodomain helicase DNA binding protein 7
  chromosome 14 open reading frame 93
  chromosome 19 open reading frame 53
  codanin 1
  coiled-coil and C2 domain containing 2B
  collagen beta(1-O)galactosyltransferase 1
  COPI coat complex subunit gamma 1
  cullin 4A
  cyclin dependent kinase 2 associated protein 1
  DDB1 and CUL4 associated factor 1
  DEAD-box helicase 20
  DEAD-box helicase 24
  DEAD-box helicase 28
  DEAD-box helicase 47
  DEK proto-oncogene
  developmental pluripotency associated 4
  DExH-box helicase 29
  DNA polymerase alpha 2, accessory subunit
  DNA topoisomerase I
  DnaJ heat shock protein family (Hsp40) member A2
  DnaJ heat shock protein family (Hsp40) member A3
  dpy-30 histone methyltransferase complex regulatory subunit
  dynein axonemal assembly factor 2
  dynein cytoplasmic 1 light intermediate chain 1
  E1A binding protein p400
  Ecm29 proteasome adaptor and scaffold
  ELKS/RAB6-interacting/CAST family member 1
  elongator acetyltransferase complex subunit 3
  elongin C
  EMG1 N1-specific pseudouridine methyltransferase
  euchromatic histone lysine methyltransferase 2
  eukaryotic translation initiation factor 3 subunit D
  eukaryotic translation initiation factor 5B
  FA complementation group I
  family with sequence similarity 71 member B
  FAST kinase domains 5
  FKBP prolyl isomerase 7
  forkhead box D3
  GCN1 activator of EIF2AK4
  general transcription factor IIIC subunit 3
  general transcription factor IIIC subunit 4
  glucosidase II alpha subunit
  H3 clustered histone 13
  H3 clustered histone 14
  H3 clustered histone 15
  haloacid dehalogenase like hydrolase domain containing 5
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  helicase like transcription factor
  high mobility group AT-hook 2
  importin 8
  inhibitor of Bruton tyrosine kinase
  INO80 complex ATPase subunit
  integral membrane protein 2B
  itchy E3 ubiquitin protein ligase
  KDEL endoplasmic reticulum protein retention receptor 2
  L-2-hydroxyglutarate dehydrogenase
  LEM domain containing 3
  LETM1 domain containing 1
  leucine rich repeat containing 41
  leucine rich repeat kinase 2
  LSM family member 14B
  lysine acetyltransferase 7
  lysine demethylase 2B
  MAP7 domain containing 1
  methyl-CpG binding domain protein 3
  methylcrotonoyl-CoA carboxylase 2
  mitochondrial ribosomal protein L17
  mitochondrial ribosomal protein L47
  mitochondrial ribosomal protein L9
  mitochondrial ribosomal protein S10
  mitochondrial ribosomal protein S15
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S34
  mitochondrial ribosomal protein S35
  mucin 16, cell surface associated
  Myb related transcription factor, partner of profilin
  myeloid leukemia factor 2
  NADH:ubiquinone oxidoreductase complex assembly factor 4
  NADH:ubiquinone oxidoreductase core subunit S7
  N-alpha-acetyltransferase 50, NatE catalytic subunit
  non-SMC condensin I complex subunit D2
  non-SMC condensin II complex subunit D3
  NOP2/Sun RNA methyltransferase 5
  NOP58 ribonucleoprotein
  nuclear receptor corepressor 2
  nuclear receptor subfamily 2 group F member 2
  paternally expressed 10
  PAX interacting protein 1
  PC4 and SFRS1 interacting protein 1
  PDGFA associated protein 1
  pentatricopeptide repeat domain 3
  peptidylprolyl isomerase A
  peptidylprolyl isomerase B
  peroxiredoxin 3
  PML-RARA regulated adaptor molecule 1
  polybromo 1
  polycomb group ring finger 1
  potassium channel modulatory factor 1
  POU class 5 homeobox 1
  POZ/BTB and AT hook containing zinc finger 1
  pre-mRNA processing factor 3
  programmed cell death 7
  proline rich coiled-coil 1
  prolyl 3-hydroxylase 1
  prolylcarboxypeptidase
  proteasome 20S subunit beta 2
  proteasome 26S subunit, non-ATPase 10
  proteasome 26S subunit, non-ATPase 13
  proteasome 26S subunit, non-ATPase 2
  proteasome 26S subunit, non-ATPase 3
  protein kinase, DNA-activated, catalytic subunit
  protein only RNase P catalytic subunit
  protein phosphatase 2 regulatory subunit B''alpha
  protein phosphatase 6 catalytic subunit
  protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
  protocadherin related 15
  protoporphyrinogen oxidase
  purine rich element binding protein A
  purine rich element binding protein B
  pyruvate dehydrogenase phosphatase regulatory subunit
  RAB13, member RAS oncogene family
  RAD23 homolog B, nucleotide excision repair protein
  regulation of nuclear pre-mRNA domain containing 1A
  ribosomal L1 domain containing 1
  ribosomal protein L22
  ribosomal protein L24
  ribosomal protein L29
  ribosomal protein L30
  ribosomal protein L31
  ribosomal protein L38
  ribosomal protein S19
  ribosomal protein S23
  ribosomal protein S25
  ribosomal protein S7
  ribosomal RNA processing 12 homolog
  ribulose-5-phosphate-3-epimerase
  ring finger protein 2
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding motif protein 17
  RNA binding motif protein 27
  RNA binding motif protein 4
  SAS-6 centriolar assembly protein
  Scm polycomb group protein like 2
  serine and arginine rich splicing factor 3
  SET domain bifurcated histone lysine methyltransferase 1
  SH3 domain containing GRB2 like 1, endophilin A2
  signal induced proliferation associated 1 like 2
  signal recognition particle 14
  signal recognition particle 9
  SIN3 transcription regulator family member A
  SIN3-HDAC complex associated factor
  small nuclear ribonucleoprotein polypeptide A'
  small nuclear ribonucleoprotein polypeptide B2
  spalt like transcription factor 1
  spalt like transcription factor 2
  spalt like transcription factor 3
  spalt like transcription factor 4
  sperm antigen with calponin homology and coiled-coil domains 1
  SR-related CTD associated factor 11
  SRY-box transcription factor 10
  SRY-box transcription factor 2
  SRY-box transcription factor 21
  SRY-box transcription factor 8
  staufen double-stranded RNA binding protein 1
  STIP1 homology and U-box containing protein 1
  stromal cell derived factor 4
  structural maintenance of chromosomes 3
  structural maintenance of chromosomes 4
  SURP and G-patch domain containing 1
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  SYF2 pre-mRNA splicing factor
  t-complex 1
  TELO2 interacting protein 1
  thioredoxin
  thyroid hormone receptor interactor 13
  TIA1 cytotoxic granule associated RNA binding protein
  TIA1 cytotoxic granule associated RNA binding protein like 1
  TNF receptor associated factor 7
  torsin family 3 member A
  trafficking protein particle complex 5
  transcription elongation regulator 1
  transcription factor 20
  transcription factor 4
  transcription factor 7 like 1
  transcription factor B2, mitochondrial
  transformer 2 beta homolog
  translocated promoter region, nuclear basket protein
  tripartite motif containing 28
  tripeptidyl peptidase 2
  tRNA methyltransferase 10C, mitochondrial RNase P subunit
  tRNA methyltransferase 6
  TSC complex subunit 2
  tubulin alpha 1a
  tubulin alpha 1c
  tubulin beta 2B class IIb
  tubulin beta 3 class III
  tubulin beta 4A class IVa
  tubulin beta 4B class IVb
  tubulin beta 8 class VIII
  tubulin beta class I
  tubulin gamma 1
  tubulin gamma complex associated protein 3
  tubulin gamma complex associated protein 4
  tumor protein p53 binding protein 1
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 34
  ubiquitin specific peptidase 42
  ubiquitin specific peptidase 7
  ubiquitin specific peptidase 9 X-linked
  UPF1 RNA helicase and ATPase
  WD repeat domain 5
  WW domain containing E3 ubiquitin protein ligase 2
  XPC complex subunit, DNA damage recognition and repair factor
  YEATS domain containing 2
  YEATS domain containing 4
  Zic family member 2
  Zic family member 3
  Zic family member 5
  zinc finger and BTB domain containing 2
  zinc finger and BTB domain containing 47
  zinc finger CCCH-type and G-patch domain containing
  zinc finger protein 143
  zinc finger protein 157
  zinc finger protein 281
  zinc finger protein 467
  zinc finger protein 865

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.