EIF5B, eukaryotic translation initiation factor 5B

EIF5B, eukaryotic translation initiation factor 5B

• Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]

• Gene Synonyms (eukaryotic translation initiation factor 5B, eIF-5B, translation initiation factor IF-2, translation initiation factor IF2, IF2,)
• NCBI Gene ID: 9669
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8N5A0
  UNIPROT ID#>>O60841
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

eukaryotic translation initiation factor 5B interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  ATP binding cassette subfamily F member 2
  bromodomain containing 7
  cap methyltransferase 1
  CDC42 small effector 1
  chromosome 1 open reading frame 131
  cornulin
  cullin 7
  cullin associated and neddylation dissociated 1
  DExD/H-box helicase 60
  eukaryotic translation initiation factor 3, subunit A
  eukaryotic translation initiation factor 5B
  F-box and WD repeat domain containing 7
  FtsJ RNA 2'-O-methyltransferase 3
  kinase suppressor of ras 1
  leucine rich repeat containing G protein-coupled receptor 4
  microtubule associated scaffold protein 2
  mitogen-activated protein kinase 13
  MMS19 homolog, cytosolic iron-sulfur assembly component
  NHP2 ribonucleoprotein
  NOP53 ribosome biogenesis factor
  obscurin like cytoskeletal adaptor 1
  PAX interacting protein 1
  PIH1 domain containing 1
  polo like kinase 2
  pre-mRNA processing factor 8
  protein inhibitor of activated STAT 4
  PTEN induced kinase 1
  pyrin and HIN domain family member 1
  ras homolog family member J
  ribosomal protein L35
  ribosomal RNA processing 12 homolog
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  signal regulatory protein alpha
  sirtuin 7
  staphylococcal nuclease and tudor domain containing 1
  tetratricopeptide repeat domain 29
  TNF receptor associated protein 1
  tumor suppressing subtransferable candidate 4
  ubiquitin protein ligase E3 component n-recognin 4
  WW domain containing E3 ubiquitin protein ligase 2
  zinc finger and BTB domain containing 3
  zinc finger and BTB domain containing 38
  zinc finger protein 574

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.