MSH2, mutS homolog 2

MSH2, mutS homolog 2

• This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

• Gene Synonyms (COCA1, FCC1, HNPCC, HNPCC1, LCFS2, hMSH2, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh2 transcript, mutS homolog 2, colon cancer, nonpolyposis type 1,)
• NCBI Gene ID: 4436
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P43246
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mutS homolog 2 interacts with:

• AAR2 splicing factor
  amyloid beta precursor protein binding protein 2
  ATR interacting protein
  BRCA1 interacting protein C-terminal helicase 1
  bromodomain containing 7
  cell division cycle 14B
  centrosomal protein 19
  checkpoint kinase 2
  coiled-coil domain containing 8
  cullin 2
  cytokine induced apoptosis inhibitor 1
  denticleless E3 ubiquitin protein ligase homolog
  DNA polymerase kappa
  DNA topoisomerase I
  DNA topoisomerase II alpha
  DNA topoisomerase II beta
  DNA topoisomerase III alpha
  DnaJ heat shock protein family (Hsp40) member C9
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation initiation factor 3 subunit B
  exonuclease 1
  Fas associated factor family member 2
  H3 clustered histone 1
  H4 clustered histone 1
  histone deacetylase 6
  limb development membrane protein 1 like
  methyltransferase like 3
  minichromosome maintenance 8 homologous recombination repair factor
  minichromosome maintenance 9 homologous recombination repair factor
  mutS homolog 2
  mutS homolog 3
  mutY DNA glycosylase
  MYC proto-oncogene, bHLH transcription factor
  nardilysin convertase
  negative elongation factor complex member B
  neurotrophic receptor tyrosine kinase 1
  nibrin
  NMD3 ribosome export adaptor
  nuclear receptor subfamily 2 group C member 2
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  phosphodiesterase 3A
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  PMS1 homolog 1, mismatch repair system component
  PMS1 homolog 2, mismatch repair system component
  prefoldin subunit 4
  proliferating cell nuclear antigen
  proliferating cell nuclear antigen
  protein kinase C zeta
  protein tyrosine phosphatase 4A3
  RAD1 checkpoint DNA exonuclease
  RAD18 E3 ubiquitin protein ligase
  RAD21 cohesin complex component
  RAD50 double strand break repair protein
  RAD51 recombinase
  RAD9 checkpoint clamp component A
  Raf-1 proto-oncogene, serine/threonine kinase
  RecQ like helicase
  RecQ like helicase 4
  replication factor C subunit 1
  replication protein A1
  replication protein A2
  replication protein A3
  replication protein A4
  REV1 DNA directed polymerase
  ribonuclease P/MRP subunit p14
  ribosomal protein lateral stalk subunit P0
  ribosomal protein S24
  ribosomal protein S5
  ring finger protein 126
  RNA binding motif protein 25
  RPGRIP1 like
  Sec23 homolog A, COPII coat complex component
  septin 9
  serine and arginine rich splicing factor 10
  serine and arginine rich splicing factor 11
  serine and arginine rich splicing factor 5
  serine and arginine rich splicing factor 7
  signal transducer and activator of transcription 3
  sirtuin 6
  sirtuin 7
  SLX4 structure-specific endonuclease subunit
  small ubiquitin like modifier 2
  snail family transcriptional repressor 1
  SNW domain containing 1
  solute carrier family 25 member 1
  sorting nexin 27
  spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP
  SPT16 homolog, facilitates chromatin remodeling subunit
  SPT5 homolog, DSIF elongation factor subunit
  ST13 Hsp70 interacting protein
  staufen double-stranded RNA binding protein 1
  structural maintenance of chromosomes 1A
  survival of motor neuron 1, telomeric
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  testin LIM domain protein
  thymidine kinase 1
  thyroid hormone receptor interactor 13
  TNF superfamily member 13b
  TOR signaling pathway regulator
  tripartite motif containing 14
  tripartite motif containing 25
  tripartite motif containing 28
  tripartite motif containing 29
  tripeptidyl peptidase 2
  tumor protein p53
  tumor protein, translationally-controlled 1
  ubiquitin conjugating enzyme E2 M
  ubiquitin like with PHD and ring finger domains 1
  ubiquitin specific peptidase 10
  UBX domain protein 8
  vir like m6A methyltransferase associated
  WT1 associated protein
  WW domain containing oxidoreductase
  XPA, DNA damage recognition and repair factor
  X-ray repair cross complementing 5
  zinc finger and BTB domain containing 38
  zinc finger containing ubiquitin peptidase 1
  zinc finger protein 746
  zw10 kinetochore protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.