GBF1, golgi brefeldin A resistant guanine nucleotide exchange factor 1

GBF1, golgi brefeldin A resistant guanine nucleotide exchange factor 1

• This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

• Gene Synonyms (Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1, BFA-resistant GEF 1, ARF1GEF,)
• NCBI Gene ID: 8729
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q92538
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

golgi brefeldin A resistant guanine nucleotide exchange factor 1 interacts with:

• 5'-3' exoribonuclease 1
  activating signal cointegrator 1 complex subunit 3
  ADP ribosylation factor GTPase activating protein 1
  AHNAK nucleoprotein
  AHNAK nucleoprotein 2
  ankyrin repeat domain 17
  AP2 associated kinase 1
  armadillo like helical domain containing 3
  ATP binding cassette subfamily F member 3
  autophagy related 2B
  baculoviral IAP repeat containing 6
  BAG cochaperone 3
  Bet1 golgi vesicular membrane trafficking protein
  beta-transducin repeat containing E3 ubiquitin protein ligase
  calcyclin binding protein
  CD2 associated protein
  cell cycle and apoptosis regulator 2
  cell division cycle 73
  cellular inhibitor of PP2A
  chaperonin containing TCP1 subunit 8
  chromatin target of PRMT1
  chromosome 11 open reading frame 49
  clathrin interactor 1
  coiled-coil domain containing 25
  coiled-coil serine rich 2
  COPI coat complex subunit gamma 1
  COPI coat complex subunit gamma 2
  coronin 1B
  coronin 1C
  CTD phosphatase subunit 1
  cyclase associated actin cytoskeleton regulatory protein 1
  cyclic GMP-AMP synthase
  cytoskeleton associated protein 5
  delta like non-canonical Notch ligand 2
  DENN domain containing 4C
  DExH-box helicase 29
  diaphanous related formin 3
  discs large MAGUK scaffold protein 5
  drebrin like
  dynactin subunit 2
  dynamin binding protein
  ecdysoneless cell cycle regulator
  Ecm29 proteasome adaptor and scaffold
  EF-hand domain family member D2
  egl-9 family hypoxia inducible factor 3
  ELKS/RAB6-interacting/CAST family member 1
  elongator acetyltransferase complex subunit 4
  elongator acetyltransferase complex subunit 5
  elongator acetyltransferase complex subunit 6
  epidermal growth factor receptor pathway substrate 15 like 1
  erbb2 interacting protein
  ethylmalonyl-CoA decarboxylase 1
  eukaryotic translation initiation factor 3 subunit M
  eukaryotic translation initiation factor 4E family member 2
  family with sequence similarity 91 member A1
  family with sequence similarity 98 member A
  F-box and WD repeat domain containing 11
  F-box protein 7
  fermitin family member 2
  forkhead box B1
  forkhead box I2
  GCN1 activator of EIF2AK4
  gem nuclear organelle associated protein 5
  general transcription factor IIIC subunit 5
  golgin A5
  GRB10 interacting GYF protein 2
  GTPase activating protein and VPS9 domains 1
  HAUS augmin like complex subunit 6
  heat shock protein family H (Hsp110) member 1
  histone deacetylase 6
  importin 7
  importin 9
  influenza virus NS1A binding protein
  isoleucyl-tRNA synthetase 2, mitochondrial
  Jupiter microtubule associated homolog 1
  Jupiter microtubule associated homolog 2
  kelch repeat and BTB domain containing 7
  kinesin family member 15
  kinesin family member 4A
  kinesin light chain 2
  KN motif and ankyrin repeat domains 2
  La ribonucleoprotein 1, translational regulator
  LIM and calponin homology domains 1
  LIM domain and actin binding 1
  LY6/PLAUR domain containing 3
  MAP7 domain containing 3
  mast cell immunoglobulin like receptor 1
  myocardin related transcription factor B
  myoferlin
  myopalladin
  NCK associated protein 1
  non-SMC condensin I complex subunit H
  nuclear distribution C, dynein complex regulator
  nucleophosmin/nucleoplasmin 3
  nucleoporin 133
  nucleoporin 85
  NUMB like endocytic adaptor protein
  parvin alpha
  PAT1 homolog 1, processing body mRNA decay factor
  patatin like phospholipase domain containing 2
  PDGFA associated protein 1
  PDZ and LIM domain 5
  PDZ and LIM domain 7
  perilipin 3
  phosphoinositide kinase, FYVE-type zinc finger containing
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  pleckstrin homology domain containing A4
  PNKD metallo-beta-lactamase domain containing
  poly(U) binding splicing factor 60
  pre-mRNA processing factor 31
  pre-mRNA processing factor 4
  programmed cell death 5
  proline rich coiled-coil 2C
  protein arginine methyltransferase 7
  protein phosphatase methylesterase 1
  proton activated chloride channel 1
  pseudouridine synthase 7
  RAB, member RAS oncogene family like 6
  Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
  receptor interacting serine/threonine kinase 4
  Rho guanine nucleotide exchange factor 16
  ribosomal protein L35
  ribosomal protein L7 like 1
  ribosomal protein S27 like
  RNA binding motif protein 26
  RNA polymerase II associated protein 3
  SCY1 like pseudokinase 2
  sec1 family domain containing 1
  SEC23 interacting protein
  septin 11
  septin 9
  sequestosome 1
  serine/threonine kinase 38
  serine/threonine kinase receptor associated protein
  shootin 1
  solute carrier family 30 member 5
  solute carrier family 30 member 6
  spartin
  sperm acrosome associated 1
  STE20 like kinase
  switching B cell complex subunit SWAP70
  TBC1 domain family member 15
  tetratricopeptide repeat domain 28
  tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
  thioredoxin like 1
  TOR signaling pathway regulator
  transport and golgi organization 6 homolog
  tripartite motif family like 2
  tubulin alpha 1c
  ubiquitin associated protein 2
  ubiquitin specific peptidase 14
  ubiquitin specific peptidase 15
  unc-45 myosin chaperone A
  valosin containing protein interacting protein 1
  vir like m6A methyltransferase associated
  WD repeat domain 11
  WD repeat domain 45
  WD repeat domain, phosphoinositide interacting 2
  YTH domain containing 2
  zinc finger and BTB domain containing 33
  zinc finger CCCH-type containing, antiviral 1
  zyg-11 family member B, cell cycle regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.