KANK2, KN motif and ankyrin repeat domains 2

KANK2, KN motif and ankyrin repeat domains 2

• This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair. [provided by RefSeq, Jul 2016]

• Gene Synonyms (KN motif and ankyrin repeat domain-containing protein 2, SRC-interacting protein, SRC1-interacting protein, ankyrin repeat domain-containing protein 25, kidney ankyrin repeat-containing protein 2, matrix-remodeling-associated protein 3, ANKRD25, MXRA3, NPHS16, PPKWH, SIP,)
• NCBI Gene ID: 25959
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q63ZY3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

KN motif and ankyrin repeat domains 2 interacts with:

• ABI family member 3
  ADP ribosylation factor like GTPase 14 effector protein
  anaphase promoting complex subunit 16
  ankyrin repeat and SOCS box containing 15
  ankyrin repeat domain 11
  ANTXR cell adhesion molecule 1
  apoptosis enhancing nuclease
  baculoviral IAP repeat containing 7
  Bardet-Biedl syndrome 7
  BEN domain containing 7
  BLOC-1 related complex subunit 6
  caspase recruitment domain family member 10
  caspase recruitment domain family member 9
  cell division cycle 20B
  centrobin, centriole duplication and spindle assembly protein
  centrosomal protein 55
  centrosomal protein 63
  centrosomal protein 70
  chromobox 8
  chromosome 11 open reading frame 1
  chromosome 2 open reading frame 68
  coiled-coil domain containing 33
  coiled-coil domain containing 57
  coiled-coil domain containing 88B
  coiled-coil-helix-coiled-coil-helix domain containing 3
  component of oligomeric golgi complex 6
  cutC copper transporter
  CWF19 like cell cycle control factor 2
  cyclin dependent kinase 2 interacting protein
  cyclin dependent kinase like 3
  cysteine rich hydrophobic domain 2
  cytohesin 4
  decapping mRNA 1A
  decapping mRNA 1B
  deltex E3 ubiquitin ligase 2
  DLG associated protein 3
  DNA damage inducible transcript 4 like
  DPEP2 neighbor
  dynein light chain LC8-type 1
  dynein light chain LC8-type 2
  EF-hand domain containing 2
  FAM161 centrosomal protein A
  family with sequence similarity 90 member A1
  forkhead box K1
  G kinase anchoring protein 1
  G protein signaling modulator 1
  GADD45G interacting protein 1
  gem nuclear organelle associated protein 4
  geminin DNA replication inhibitor
  germ cell-less 1, spermatogenesis associated
  golgin A6 family like 9
  golgin A6 family member A
  G-patch domain and KOW motifs
  interactor of HORMAD1 1
  keratin 27
  keratin 40
  keratin associated protein 6-3
  kinesin family member 21A
  kinesin family member 9
  KN motif and ankyrin repeat domains 2
  L3MBTL histone methyl-lysine binding protein 3
  leukocyte receptor cluster member 1
  LIM domain only 3
  mediator complex subunit 19
  mediator complex subunit 4
  microtubule interacting and trafficking domain containing 1
  mitochondrial coiled-coil domain 1
  MOB kinase activator 1A
  MOB kinase activator 3C
  MORN repeat containing 3
  MSS51 mitochondrial translational activator
  myozenin 3
  N-terminal EF-hand calcium binding protein 2
  nuclear receptor coactivator 5
  NUT midline carcinoma family member 1
  pellino E3 ubiquitin protein ligase family member 3
  pleckstrin homology domain containing A2
  PR/SET domain 14
  PR/SET domain 6
  pre-mRNA processing factor 31
  proline rich 5 like
  receptor interacting serine/threonine kinase 4
  scavenger receptor class A member 5
  Sec24 related gene family, member C (S. cerevisiae)
  SERTA domain containing 3
  sodium channel modifier 1
  SSX family member 2 interacting protein
  synaptotagmin 6
  taxilin alpha
  testis expressed 11
  testis specific 10
  testis specific 10 interacting protein
  THAP domain containing 1
  THAP domain containing 6
  thrombospondin type 1 domain containing 4
  TRAF interacting protein with forkhead associated domain
  transcription factor Dp family member 3
  tribbles pseudokinase 3
  tripartite motif containing 54
  tropomodulin 4
  TSPY like 6
  ubiquitin associated protein 2
  USH1 protein network component harmonin binding protein 1
  vimentin type intermediate filament associated coiled-coil protein
  von Willebrand factor C domain containing 2
  WASH complex subunit 1
  ZFP57 zinc finger protein
  zinc finger and BTB domain containing 42
  zinc finger matrin-type 2
  zinc finger MYND-type containing 12
  zinc finger protein 414
  zinc finger protein 512
  zinc finger protein 648
  zinc finger protein 774
  zinc finger protein 784
  zinc finger RANBP2-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.