ITGB3BP, integrin subunit beta 3 binding protein

ITGB3BP, integrin subunit beta 3 binding protein

• This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

• Gene Synonyms (centromere protein R, beta 3 endonexin, beta3-endonexin, integrin beta 3 binding protein (beta3-endonexin), integrin beta-3-binding protein, nuclear receptor-interacting factor 3, CENP-R, CENPR, HSU37139, NRIF3, TAP20,)
• NCBI Gene ID: 23421
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13352
  UNIPROT ID#>>D3DQ59
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

integrin subunit beta 3 binding protein interacts with:

• ADP ribosylation factor interacting protein 2
  ankyrin repeat domain 11
  centromere protein H
  centromere protein K
  centromere protein N
  centromere protein O
  centromere protein P
  centromere protein Q
  centromere protein T
  centromere protein U
  chromosome 14 open reading frame 119
  DEAD-box helicase 24
  DGCR8 microprocessor complex subunit
  EF-hand domain containing 1
  GTP binding protein 3, mitochondrial
  integrin subunit beta 3 binding protein
  leucine rich repeat kinase 2
  mesogenin 1
  NRDE-2, necessary for RNA interference, domain containing
  N-terminal glutamine amidase 1
  periphilin 1
  PIH1 domain containing 2
  protein kinase N3
  stromal cell derived factor 4
  tripartite motif family like 2
  ubiquitin conjugating enzyme E2 O
  ubiquitin protein ligase E3 component n-recognin 7
  USH1 protein network component harmonin binding protein 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.