AFG1L, AFG1 like ATPase

AFG1L, AFG1 like ATPase

• This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]

• Gene Synonyms (AFG1-like ATPase, ATPase family gene 1 homolog, CG8520 gene product, lactation elevated 1, lactation elevated protein 1, AFG1, LACE1, c222389,)
• NCBI Gene ID: 246269
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WV93
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

AFG1 like ATPase interacts with:

• AFG1 like ATPase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.