GARS1, glycyl-tRNA synthetase 1

GARS1, glycyl-tRNA synthetase 1

• This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

• Gene Synonyms (CMT2D, DSMAV, GARS, GlyRS, HMN5, SMAD1, glycine--tRNA ligase, AP-4-A synthetase, Charcot-Marie-Tooth neuropathy 2D, Charcot-Marie-Tooth neuropathy, neuronal type, D, ap4A synthetase, diadenosine tetraphosphate synthetase,)
• NCBI Gene ID: 2617
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A090N8G0
  UNIPROT ID#>>P41250
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glycyl-tRNA synthetase 1 interacts with:

• AAR2 splicing factor
  acyl-CoA dehydrogenase family member 10
  anoctamin 7
  anterior gradient 2, protein disulphide isomerase family member
  arginyl-tRNA synthetase 1
  armadillo repeat containing 1
  asparaginyl-tRNA synthetase 1
  BOP1 ribosomal biogenesis factor
  coronin 1C
  cullin 5
  cullin 7
  cullin associated and neddylation dissociated 1
  cytokine induced apoptosis inhibitor 1
  decapping mRNA 2
  elongation factor Tu GTP binding domain containing 2
  exportin 7
  Fas binding factor 1
  F-box protein 6
  general transcription factor IIA subunit 1
  glucosidase II alpha subunit
  glutamine--fructose-6-phosphate transaminase 1
  glutaminyl-tRNA synthetase 1
  glycogen synthase kinase 3 beta
  golgi reassembly stacking protein 2
  H4 clustered histone 1
  heat shock protein family A (Hsp70) member 4 like
  heat shock protein family A (Hsp70) member 8
  heat shock protein family B (small) member 1
  heat shock protein family B (small) member 2
  HEXIM P-TEFb complex subunit 1
  HIRA interacting protein 3
  histidyl-tRNA synthetase 1
  histidyl-tRNA synthetase 2, mitochondrial
  histone deacetylase 4
  histone deacetylase 6
  histone deacetylase 6
  HSPA (Hsp70) binding protein 1
  isoleucyl-tRNA synthetase 1
  KH-type splicing regulatory protein
  leucine carboxyl methyltransferase 2
  leucyl-tRNA synthetase 1
  malic enzyme 1
  methionyl-tRNA synthetase 1
  methylphosphate capping enzyme
  mitogen-activated protein kinase 8
  mitogen-activated protein kinase kinase kinase 10
  MYC proto-oncogene, bHLH transcription factor
  myotrophin
  NDRG family member 3
  NEDD8 activating enzyme E1 subunit 1
  NEDD8 ubiquitin like modifier
  nephrocystin 1
  neurotrophic receptor tyrosine kinase 1
  NMD3 ribosome export adaptor
  NPL4 homolog, ubiquitin recognition factor
  nuclear cap binding protein subunit 1
  nuclear receptor subfamily 2 group C member 2
  nucleoporin 50
  OFD1 centriole and centriolar satellite protein
  oxysterol binding protein
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  POC5 centriolar protein
  prohibitin
  proteasome 20S subunit alpha 3
  proteasome 26S subunit, ATPase 3
  proteasome activator subunit 1
  proteasome activator subunit 2
  protein disulfide isomerase family A member 3
  protein phosphatase, Mg2+/Mn2+ dependent 1G
  PTEN induced kinase 1
  RecQ like helicase 4
  ring finger protein 123
  Ro60, Y RNA binding protein
  RPGRIP1 like
  Sec23 homolog A, COPII coat complex component
  serine hydroxymethyltransferase 1
  SERPINE1 mRNA binding protein 1
  snail family transcriptional repressor 1
  sorting nexin 1
  spindle and centriole associated protein 1
  staufen double-stranded RNA binding protein 1
  target of myb1 membrane trafficking protein
  tectonic family member 1
  tectonic family member 3
  tetratricopeptide repeat domain 1
  threonyl-tRNA synthetase 1
  threonyl-tRNA synthetase 3
  thymopoietin
  trinucleotide repeat containing adaptor 6B
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 N
  ubiquitin like modifier activating enzyme 1
  ubiquitin recognition factor in ER associated degradation 1
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 14
  UDP-glucose 6-dehydrogenase
  unk zinc finger
  vesicle amine transport 1
  VHL binding protein 1
  vir like m6A methyltransferase associated
  WW domain containing oxidoreductase
  X-prolyl aminopeptidase 1
  zyxin

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.