PTPN22, protein tyrosine phosphatase non-receptor type 22

PTPN22, protein tyrosine phosphatase non-receptor type 22

• This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]

• Gene Synonyms (tyrosine-protein phosphatase non-receptor type 22, PEST-domain phosphatase, hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, lymphoid-specific protein tyrosine phosphatase, protein tyrosine phosphatase, non-receptor type 22 (lymphoid), protein tyrosine phosphatase, non-receptor type 8, LYP, LYP1, LYP2, PEP, PTPN22.5, PTPN22.6, PTPN8,)
• NCBI Gene ID: 26191
• Species: Homo sapiens (Human)
• UNIPROT ID#>>G3K0T4
  UNIPROT ID#>>Q9Y2R2
  UNIPROT ID#>>B4DZW8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein tyrosine phosphatase non-receptor type 22 interacts with:

• acyl-CoA dehydrogenase family member 8
  coiled-coil domain containing 138
  kinesin family member 7
  leucine zipper tumor suppressor 2
  matrix AAA peptidase interacting protein 1
  mediator complex subunit 4
  mindbomb E3 ubiquitin protein ligase 1
  protein tyrosine phosphatase non-receptor type 22
  ribosomal protein S19 binding protein 1
  sideroflexin 4
  solute carrier family 25 member 19
  SSX family member 2 interacting protein
  stromal cell derived factor 4
  TBC1 domain family member 31

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.