GLDC, glycine decarboxylase

GLDC, glycine decarboxylase

• Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]

• Gene Synonyms (glycine dehydrogenase (decarboxylating), mitochondrial, glycine cleavage system protein P, glycine decarboxylase P-protein, glycine dehydrogenase (aminomethyl-transferring), glycine dehydrogenase [decarboxylating], mitochondrial, nonketotic hyperglycinemia, GCE, GCSP, HYGN1,)
• NCBI Gene ID: 2731
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P23378
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glycine decarboxylase interacts with:

• cullin 2
  DNA polymerase gamma 2, accessory subunit
  glycine decarboxylase
  mitochondrial rRNA methyltransferase 1
  NADH:ubiquinone oxidoreductase subunit AB1
  neurotrophic receptor tyrosine kinase 1
  nudix hydrolase 6
  oxidoreductase like domain containing 1
  pleckstrin homology domain containing A4
  RecQ like helicase 4
  sclerostin
  small nuclear ribonucleoprotein 13
  spermatogenesis associated 13
  SUZ12 polycomb repressive complex 2 subunit
  TNF alpha induced protein 3
  toll like receptor 10

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.