CXCL1, C-X-C motif chemokine ligand 1

CXCL1, C-X-C motif chemokine ligand 1

• This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

• Gene Synonyms (growth-regulated alpha protein, C-X-C motif chemokine 1, GRO-alpha(1-73), GRO1 oncogene (melanoma growth stimulating activity, alpha), GRO1 oncogene (melanoma growth-stimulating activity), MGSA alpha, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), fibroblast secretory protein, melanoma growth stimulating activity, alpha, melanoma growth stimulatory activity alpha, neutrophil-activating protein 3, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1,)
• NCBI Gene ID: 2919
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P09341
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

C-X-C motif chemokine ligand 1 interacts with:

• C-X-C motif chemokine ligand 1
  C-X-C motif chemokine receptor 1
  C-X-C motif chemokine receptor 2
  homeodomain interacting protein kinase 2
  HRas proto-oncogene, GTPase
  matrix metallopeptidase 9
  mesenchyme homeobox 2
  phosphatase and tensin homolog
  ring-box 1
  serine and arginine rich splicing factor 1
  X-ray repair cross complementing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.