NRG1, neuregulin 1

NRG1, neuregulin 1

• The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]

• Gene Synonyms (pro-neuregulin-1, membrane-bound isoform, acetylcholine receptor-inducing activity, glial growth factor 2, heregulin, alpha (45kD, ERBB2 p185-activator), neu differentiation factor, pro-NRG1, sensory and motor neuron derived factor, ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF,)
• NCBI Gene ID: 3084
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F6RJN6
  UNIPROT ID#>>B0FYA7
  UNIPROT ID#>>A6MW56
  UNIPROT ID#>>B0FYA8
  UNIPROT ID#>>Q02297
  UNIPROT ID#>>B7Z1D7
  UNIPROT ID#>>Q7RTW5
  UNIPROT ID#>>E3SFM9
  UNIPROT ID#>>B7Z1E3
  UNIPROT ID#>>A5YAK8
  UNIPROT ID#>>B0FYA9
  UNIPROT ID#>>Q7RTW3
  UNIPROT ID#>>Q6PK61
  UNIPROT ID#>>A6MW54
  UNIPROT ID#>>A5YAK6
  UNIPROT ID#>>A0A024QY88
  UNIPROT ID#>>A6MW55
  UNIPROT ID#>>B0FWZ3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

neuregulin 1 interacts with:

• ADAM metallopeptidase domain 19
  adhesion G protein-coupled receptor L1
  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
  ATP binding cassette subfamily B member 10
  beta-1,3-N-acetylgalactosaminyltransferase 2
  C1GALT1 specific chaperone 1
  calcyon neuron specific vesicular protein
  CDGSH iron sulfur domain 2
  contactin associated protein family member 3
  delta 4-desaturase, sphingolipid 1
  dermatan sulfate epimerase
  dynein axonemal assembly factor 5
  erb-b2 receptor tyrosine kinase 4
  family with sequence similarity 234 member B
  glomulin, FKBP associated protein
  heme oxygenase 1
  heparan sulfate 6-O-sulfotransferase 1
  IKAROS family zinc finger 4
  integrator complex subunit 7
  jagunal homolog 1
  KIAA2013
  LARGE xylosyl- and glucuronyltransferase 2
  LEM domain containing 3
  leucine rich repeat containing G protein-coupled receptor 4
  LIM domain kinase 1
  lipolysis stimulated lipoprotein receptor
  lysosomal protein transmembrane 4 beta
  major histocompatibility complex, class II, DP beta 1
  membrane bound O-acyltransferase domain containing 7
  membrane spanning 4-domains A4A
  mitochondrial carrier 1
  myosin XIX
  NADH:ubiquinone oxidoreductase subunit A3
  neuropilin and tolloid like 2
  NIMA related kinase 4
  NRAS proto-oncogene, GTPase
  outer mitochondrial membrane lipid metabolism regulator OPA3
  phosphatidylinositol glycan anchor biosynthesis class U
  polypeptide N-acetylgalactosaminyltransferase 11
  post-GPI attachment to proteins inositol deacylase 1
  protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
  protein O-mannosyltransferase 1
  proteolipid protein 1
  retinol dehydrogenase 11
  Rho related BTB domain containing 3
  ring finger protein 130
  serine palmitoyltransferase long chain base subunit 2
  sideroflexin 3
  solute carrier family 22 member 18
  solute carrier family 25 member 16
  solute carrier family 25 member 23
  solute carrier family 35 member B2
  solute carrier family 38 member 10
  sterol regulatory element binding transcription factor 2
  TM2 domain containing 3
  transmembrane O-mannosyltransferase targeting cadherins 3
  transmembrane O-mannosyltransferase targeting cadherins 4
  transmembrane protein 164
  transmembrane protein 181
  transmembrane protein 205
  transmembrane protein 39B
  transmembrane protein 54
  transmembrane protein 63B
  tubulin beta 3 class III
  ubiquinol-cytochrome c reductase complex III subunit VII
  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
  zinc finger DHHC-type palmitoyltransferase 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.