HLA-DQA1, major histocompatibility complex, class II, DQ alpha 1

HLA-DQA1, major histocompatibility complex, class II, DQ alpha 1

• HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

• Gene Synonyms (HLA class II histocompatibility antigen, DQ alpha 1 chain, DC-1 alpha chain, DC-alpha, HLA-DCA, MHC HLA-DQ alpha, MHC class II DQ alpha chain, MHC class II DQA1, MHC class II HLA-DQ-alpha-1, MHC class II antigen DQA1, MHC class II protein, truncated MHC class II antigen, CELIAC1, DQ-A1, DQA1, HLA-DQA,)
• NCBI Gene ID: 3117
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8MH44
  UNIPROT ID#>>P01909
  UNIPROT ID#>>A0A173ADG5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

major histocompatibility complex, class II, DQ alpha 1 interacts with:

• ATPase H+ transporting V0 subunit a2
  DEAD-box helicase 19B
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  ligand dependent nuclear receptor interacting factor 1
  macoilin 1
  major facilitator superfamily domain containing 8
  major histocompatibility complex, class II, DQ beta 1
  myosin XIX
  nuclear receptor subfamily 2 group F member 2
  post-GPI attachment to proteins GalNAc transferase 4
  potassium inwardly rectifying channel subfamily J member 8
  SH3 domain containing GRB2 like 2, endophilin A1
  solute carrier family 22 member 18
  solute carrier family 27 member 6
  solute carrier family 30 member 9
  solute carrier family 38 member 9
  sphingomyelin phosphodiesterase 2
  suppression of tumorigenicity 7
  TLE family member 1, transcriptional corepressor
  transmembrane protein 214
  transmembrane protein 219
  unc-119 lipid binding chaperone

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.