HNF4A, hepatocyte nuclear factor 4 alpha

HNF4A, hepatocyte nuclear factor 4 alpha

• The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]

• Gene Synonyms (hepatocyte nuclear factor 4-alpha, HNF4alpha10/11/12, TCF-14, hepatic nuclear factor 4 alpha, nuclear receptor subfamily 2 group A member 1, transcription factor 14, transcription factor HNF-4, FRTS4, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14,)
• NCBI Gene ID: 3172
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P41235
  UNIPROT ID#>>A0A087WXV4
  UNIPROT ID#>>F1D8S2
  UNIPROT ID#>>F1D8T0
  UNIPROT ID#>>F1D8T1
  UNIPROT ID#>>B9VVT8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hepatocyte nuclear factor 4 alpha interacts with:

• acidic nuclear phosphoprotein 32 family member B
  COP9 signalosome subunit 5
  elongator acetyltransferase complex subunit 3
  embryonic ectoderm development
  eukaryotic translation initiation factor 1A Y-linked
  exportin 1
  hepatocyte nuclear factor 4 alpha
  histone deacetylase 3
  histone deacetylase 4
  HNF1 homeobox A
  ISL LIM homeobox 1
  MDM2 proto-oncogene
  mediator complex subunit 1
  mediator complex subunit 10
  mediator complex subunit 14
  mediator complex subunit 16
  mediator complex subunit 17
  mediator complex subunit 21
  mediator complex subunit 23
  mediator complex subunit 24
  mediator complex subunit 7
  mitochondrial trans-2-enoyl-CoA reductase
  mitogen-activated protein kinase 1
  mitogen-activated protein kinase 3
  natriuretic peptide A
  nuclear receptor binding factor 2
  nuclear receptor coactivator 1
  nuclear receptor coactivator 2
  nuclear receptor coactivator 6
  nuclear receptor corepressor 2
  nuclear receptor interacting protein 1
  nuclear receptor subfamily 0 group B member 2
  nuclear receptor subfamily 1 group I member 2
  nuclear receptor subfamily 1 group I member 3
  nuclear receptor subfamily 2 group C member 2
  nuclear receptor subfamily 2 group F member 1
  phospholipid phosphatase 2
  poly(A) binding protein cytoplasmic 4
  PPARG coactivator 1 alpha
  PPARG coactivator 1 beta
  proline rich nuclear receptor coactivator 1
  proline rich nuclear receptor coactivator 2
  prospero homeobox 1
  proteasome 26S subunit, non-ATPase 10
  protein arginine methyltransferase 1
  protein inhibitor of activated STAT 4
  protein kinase AMP-activated catalytic subunit alpha 2
  protein kinase cAMP-activated catalytic subunit alpha
  pterin-4 alpha-carbinolamine dehydratase 1
  RAD50 double strand break repair protein
  ring finger protein 4
  serine/threonine kinase 16
  sirtuin 1
  SMAD family member 2
  SMAD family member 3
  SMAD family member 4
  Sp1 transcription factor
  sterol regulatory element binding transcription factor 1
  sterol regulatory element binding transcription factor 2
  SUB1 regulator of transcription
  SUZ12 polycomb repressive complex 2 subunit
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  synuclein gamma
  TATA-box binding protein
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 9
  transcription factor 7 like 2
  transcriptional adaptor 2A
  trimethylguanosine synthase 1
  tripartite motif containing 24
  tumor protein p53
  ubiquitin conjugating enzyme E2 I
  vitamin D receptor
  zinc finger HIT-type containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.