IFNG, interferon gamma

IFNG, interferon gamma

• This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

• Gene Synonyms (interferon gamma, IFN-gamma, immune interferon, IFG, IFI,)
• NCBI Gene ID: 3458
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P01579
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interferon gamma interacts with:

• DDB1 and CUL4 associated factor 4
  golgi associated PDZ and coiled-coil motif containing
  interferon gamma
  interferon gamma receptor 1
  interferon gamma receptor 2
  signal transducer and activator of transcription 6
  tumor necrosis factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.