IL12RB2, interleukin 12 receptor subunit beta 2

IL12RB2, interleukin 12 receptor subunit beta 2

• The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]

• Gene Synonyms (interleukin-12 receptor subunit beta-2, IL-12 receptor subunit beta-2, IL-12R subunit beta-2, interleukin 12 receptor, beta 2, interleukin-12 receptor beta-2 chain,)
• NCBI Gene ID: 3595
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0A0MTN7
  UNIPROT ID#>>B7ZB60
  UNIPROT ID#>>Q99665
  UNIPROT ID#>>B4DGA4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

interleukin 12 receptor subunit beta 2 interacts with:

• interleukin 12 receptor subunit beta 2
  Janus kinase 2
  signal transducer and activator of transcription 4
  suppressor of cytokine signaling 3

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