INSIG1, insulin induced gene 1

INSIG1, insulin induced gene 1

• This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

• Gene Synonyms (CL6, insulin-induced gene 1 protein, INSIG-1 membrane protein,)
• NCBI Gene ID: 3638
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A4D2M9
  UNIPROT ID#>>A0A024RD68
  UNIPROT ID#>>F5H6P3
  UNIPROT ID#>>O15503
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

insulin induced gene 1 interacts with:

• cytochrome p450 oxidoreductase
  ER lipid raft associated 1
  ER lipid raft associated 2
  Fas associated factor family member 2
  insulin induced gene 1
  insulin induced gene 2
  progesterone receptor membrane component 1
  proteasome 20S subunit alpha 7
  proteasome 26S subunit, ATPase 3
  protein kinase AMP-activated catalytic subunit alpha 1
  ring finger protein 139
  ring finger protein 145
  SREBF chaperone
  SREBF chaperone
  sterol O-acyltransferase 2
  sterol regulatory element binding transcription factor 1
  sterol regulatory element binding transcription factor 2
  transmembrane protein 237
  tumor protein p53
  valosin containing protein
  VAMP associated protein A
  VAMP associated protein B and C

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.