ITGA2, integrin subunit alpha 2

ITGA2, integrin subunit alpha 2

• This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

• Gene Synonyms (BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin alpha-2, CD49 antigen-like family member B, alpha 2 subunit of VLA-2 receptor, collagen receptor, human platelet alloantigen system 5, integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), platelet antigen Br, platelet glycoprotein GPIa, platelet membrane glycoprotein Ia, very late activation protein 2 receptor, alpha-2 subunit,)
• NCBI Gene ID: 3673
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P17301
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

integrin subunit alpha 2 interacts with:

• anaphase promoting complex subunit 13
  arginine and serine rich protein 1
  butyrophilin like 8
  CD46 molecule
  centromere protein H
  endoplasmic reticulum-golgi intermediate compartment 1
  galectin 3
  galectin 8
  integrin beta 1 (fibronectin receptor beta)
  integrin subunit alpha 2
  integrin subunit beta 1
  KRAS proto-oncogene, GTPase
  laminin subunit alpha 1
  lysosomal associated membrane protein 1
  MAD2L1 binding protein
  matrix metallopeptidase 1
  MGAT4 family member C
  OTU deubiquitinase with linear linkage specificity like
  proteasome 26S subunit, non-ATPase 4
  RAB interacting factor
  ring finger protein 4
  secretoglobin family 1D member 1
  serpin family A member 12
  SHANK associated RH domain interactor
  transmembrane p24 trafficking protein 6
  TSC22 domain family member 2
  vir like m6A methyltransferase associated
  von Hippel-Lindau tumor suppressor
  zinc activated ion channel

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.