LAIR1, leukocyte associated immunoglobulin like receptor 1

LAIR1, leukocyte associated immunoglobulin like receptor 1

• The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

• Gene Synonyms (CD305, LAIR-1, leukocyte-associated immunoglobulin-like receptor 1, immunoglobulin heavy chain variable region, leukocyte-associated Ig-like receptor 1,)
• NCBI Gene ID: 3903
• Species: Homo sapiens (Human)
• UNIPROT ID#>>D3YTC8
  UNIPROT ID#>>A8MZ84
  UNIPROT ID#>>Q6GTX8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

leukocyte associated immunoglobulin like receptor 1 interacts with:

• leukocyte associated immunoglobulin like receptor 1
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 6

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