SMAD7, SMAD family member 7

SMAD7, SMAD family member 7

• The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

• Gene Synonyms (CRCS3, MADH7, MADH8, mothers against decapentaplegic homolog 7, MAD (mothers against decapentaplegic, Drosophila) homolog 7, MAD homolog 8, Mothers against decapentaplegic, drosophila, homolog of, 7, SMAD, mothers against DPP homolog 7, hSMAD7, mothers against DPP homolog 8,)
• NCBI Gene ID: 4092
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B3KYA8
  UNIPROT ID#>>O15105
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SMAD family member 7 interacts with:

• ASH1 like histone lysine methyltransferase
  axin 1
  axin 2
  BMP and activin membrane bound inhibitor
  COP9 signalosome subunit 5
  cullin 4A
  cullin 4B
  CXXC finger protein 5
  erbb2 interacting protein
  hes related family bHLH transcription factor with YRPW motif like
  histone acetyltransferase 1
  histone deacetylase 3
  histone deacetylase 5
  histone deacetylase 6
  itchy E3 ubiquitin protein ligase
  lymphoid enhancer binding factor 1
  lysine acetyltransferase 2B
  lysine demethylase 2A
  maternal embryonic leucine zipper kinase
  methyl-CpG binding domain protein 1
  mitogen-activated protein kinase kinase 3
  mitogen-activated protein kinase kinase 6
  mitogen-activated protein kinase kinase kinase 7
  MYC proto-oncogene, bHLH transcription factor
  myocardin related transcription factor B
  myogenic differentiation 1
  NEDD4 E3 ubiquitin protein ligase
  NEDD4 like E3 ubiquitin protein ligase
  OTU deubiquitinase 1
  par-3 family cell polarity regulator
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 4
  protein phosphatase 1 regulatory subunit 15A
  ring finger protein 111
  ring finger protein, LIM domain interacting
  SAM and SH3 domain containing 3
  serine/threonine kinase receptor associated protein
  serum response factor
  SET domain containing 7, histone lysine methyltransferase
  sirtuin 1
  SMAD family member 7
  SMAD family member 9
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  S-phase kinase associated protein 2
  SRY-box transcription factor 13
  SRY-box transcription factor 5
  SRY-box transcription factor 7
  STAM binding protein
  STAM binding protein like 1
  T-box brain transcription factor 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  TGF-beta activated kinase 1 (MAP3K7) binding protein 3
  TNFAIP3 interacting protein 2
  toll interacting protein
  transcription factor 7 like 2
  transcription termination factor 1
  transcription termination factor 2
  transforming growth factor beta 1 induced transcript 1
  transforming growth factor beta receptor 1
  transforming growth factor beta receptor 2
  TSC22 domain family member 1
  tumor protein p53
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 O
  ubiquitin C-terminal hydrolase L5
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 15
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator
  zinc finger and BTB domain containing 11
  zinc finger and BTB domain containing 44
  zinc finger E-box binding homeobox 1
  zinc finger protein 107

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.