NR3C2, nuclear receptor subfamily 3 group C member 2

NR3C2, nuclear receptor subfamily 3 group C member 2

• This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

• Gene Synonyms (MCR, MLR, MR, NR3C2VIT, mineralocorticoid receptor, aldosterone receptor, mineralocorticoid receptor 1, mineralocorticoid receptor 2, mineralocorticoid receptor delta, nuclear receptor subfamily 3, group C, member 2 variant 3,)
• NCBI Gene ID: 4306
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P08235
  UNIPROT ID#>>A0A0D9SFL9
  UNIPROT ID#>>B0ZBF6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

nuclear receptor subfamily 3 group C member 2 interacts with:

• aryl hydrocarbon receptor interacting protein
  carnosine N-methyltransferase 1
  caspase 8 associated protein 2
  cullin associated and neddylation dissociated 1
  DnaJ heat shock protein family (Hsp40) member C7
  egl-9 family hypoxia inducible factor 3
  Fas associated factor 1
  lysine acetyltransferase 2B
  nuclear receptor coactivator 1
  nuclear receptor interacting protein 1
  peptidylprolyl isomerase D
  prospero homeobox 1
  prostaglandin E synthase 3
  proteasome 26S subunit, ATPase 5
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 3
  protein phosphatase 1 catalytic subunit alpha
  protein phosphatase 5 catalytic subunit
  Rab acceptor 1
  retinoid X receptor alpha
  small ubiquitin like modifier 1
  STIP1 homology and U-box containing protein 1
  tripartite motif containing 24
  ubiquitin conjugating enzyme E2 I
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.