TONSL, tonsoku like, DNA repair protein

TONSL, tonsoku like, DNA repair protein

• The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]

• Gene Synonyms (IKBR, NFKBIL2, SEMDSP, tonsoku-like protein, I-kappa-B-related protein, NF-kappa-B inhibitor-like protein 2, ikappaBR, inhibitor of kappa B-related protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2,)
• NCBI Gene ID: 4796
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96HA7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tonsoku like, DNA repair protein interacts with:

• anterior gradient 2, protein disulphide isomerase family member
  anti-silencing function 1A histone chaperone
  anti-silencing function 1B histone chaperone
  apoptosis inducing factor mitochondria associated 1
  DDB1 and CUL4 associated factor 15
  egl-9 family hypoxia inducible factor 3
  H2A clustered histone 4
  H2B clustered histone 1
  H2B clustered histone 13
  H3 clustered histone 1
  H3 clustered histone 6
  H3.4 histone
  H4 clustered histone 1
  macroH2A.1 histone
  macroH2A.2 histone
  MAU2 sister chromatid cohesion factor
  MMS22 like, DNA repair protein
  neurotrophic receptor tyrosine kinase 1
  pleckstrin homology domain containing A4
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  solute carrier family 25 member 3
  SPT16 homolog, facilitates chromatin remodeling subunit
  structure specific recognition protein 1
  tonsoku like, DNA repair protein
  X-ray repair cross complementing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.