OAS1, 2'-5'-oligoadenylate synthetase 1

OAS1, 2'-5'-oligoadenylate synthetase 1

• This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]

• Gene Synonyms (E18/E16, IFI-4, OIAS, OIASI, 2'-5'-oligoadenylate synthase 1, (2-5')oligo(A) synthase 1, 2',5'-oligo A synthetase 1, 2'-5'-oligoadenylate synthetase 1, 40/46kDa, 2'-5'-oligoisoadenylate synthetase 1, 2-5A synthase 1, 2-5A synthetase 1, E16 (2'-5') oligo A synthetase,)
• NCBI Gene ID: 4938
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P00973
  UNIPROT ID#>>F8VXY3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

2'-5'-oligoadenylate synthetase 1 interacts with:

• BUD23 rRNA methyltransferase and ribosome maturation factor
  component of oligomeric golgi complex 6
  exocyst complex component 5
  histone cell cycle regulator
  hook microtubule tethering protein 2
  protein arginine methyltransferase 6
  ribosomal protein L30
  RUN and FYVE domain containing 1
  tripartite motif containing 27

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.