HIRA, histone cell cycle regulator

HIRA, histone cell cycle regulator

• This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]

• Gene Synonyms (protein HIRA, DiGeorge critical region gene 1, HIR histone cell cycle regulation defective homolog A, TUP1-like enhancer of split protein 1, histone regulator A, DGCR1, TUP1, TUPLE1,)
• NCBI Gene ID: 7290
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P54198
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

histone cell cycle regulator interacts with:

• anti-silencing function 1A histone chaperone
  anti-silencing function 1B histone chaperone
  B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
  BAG cochaperone 5
  BRF2 RNA polymerase III transcription initiation factor subunit
  calcineurin binding protein 1
  CCCTC-binding factor
  cell division cycle 26
  cullin 3
  dermcidin
  DnaJ heat shock protein family (Hsp40) member A2
  galectin 7B
  H2B clustered histone 12
  H2B clustered histone 21
  H3 clustered histone 1
  H3 clustered histone 14
  H4 clustered histone 1
  H4 clustered histone 6
  HIRA interacting protein 3
  interferon induced transmembrane protein 1
  NFU1 iron-sulfur cluster scaffold
  nuclear RNA export factor 1
  O-linked N-acetylglucosamine (GlcNAc) transferase
  RNA polymerase III subunit A
  RuvB like AAA ATPase 1
  SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
  TEA domain transcription factor 2
  TRAF interacting protein with forkhead associated domain
  tripartite motif containing 25
  ubinuclein 1
  ubiquitin conjugating enzyme E2 I
  X antigen family member 1A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.