OGDH, oxoglutarate dehydrogenase

OGDH, oxoglutarate dehydrogenase

• This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

• Gene Synonyms (AKGDH, E1k, KGD1, OGDC, OGDH2, 2-oxoglutarate dehydrogenase, mitochondrial, 2-oxoglutarate dehydrogenase complex component E1, OGDC-E1, oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide), oxoglutarate decarboxylase, oxoglutarate dehydrogenase (succinyl-transferring), testicular tissue protein Li 131,)
• NCBI Gene ID: 4967
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q02218
  UNIPROT ID#>>E9PCR7
  UNIPROT ID#>>B4E3E9
  UNIPROT ID#>>A0A140VJQ5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

oxoglutarate dehydrogenase interacts with:

• alkylglycerone phosphate synthase
  anterior gradient 2, protein disulphide isomerase family member
  ATP synthase peripheral stalk subunit d
  aurora kinase A interacting protein 1
  calcium binding and coiled-coil domain 2
  cleavage and polyadenylation specific factor 7
  cytochrome b5 reductase 1
  cytochrome c oxidase assembly factor 3
  cytochrome c oxidase assembly factor COX14
  cytochrome c oxidase subunit 5A
  ER membrane protein complex subunit 2
  exosome component 5
  FKBP prolyl isomerase 9
  histone deacetylase 6
  histone deacetylase 6
  ISG15 ubiquitin like modifier
  La ribonucleoprotein 7, transcriptional regulator
  mitochondrial carrier 2
  mitochondrial contact site and cristae organizing system subunit 10
  mitochondrial ribosomal protein L13
  mitochondrial ribosomal protein L15
  mitochondrial ribosomal protein L38
  mitochondrial ribosomal protein L41
  mitochondrial ribosomal protein S2
  mitochondrial rRNA methyltransferase 1
  neutrophil cytosolic factor 1
  nipsnap homolog 1
  nuclear RNA export factor 1
  palmitoyl-protein thioesterase 1
  peroxiredoxin 3
  phospholipid scramblase 1
  prohibitin
  prohibitin 2
  prolactin regulatory element binding
  propionyl-CoA carboxylase subunit beta
  pyruvate dehydrogenase complex component X
  pyruvate dehydrogenase E1 subunit alpha 1
  pyruvate dehydrogenase E1 subunit beta
  pyruvate dehydrogenase kinase 1
  RAB1A, member RAS oncogene family
  RAB5 interacting factor
  RAB7A, member RAS oncogene family
  saccharopine dehydrogenase (putative)
  sec1 family domain containing 1
  sideroflexin 1
  single stranded DNA binding protein 1
  stomatin like 2
  succinate-CoA ligase GDP/ADP-forming subunit alpha
  succinate-CoA ligase GDP-forming subunit beta
  translocase of outer mitochondrial membrane 22
  translocase of outer mitochondrial membrane 5
  tripartite motif containing 25
  tRNA methyltransferase 61B
  TSR1 ribosome maturation factor
  ubiquinol-cytochrome c reductase complex III subunit VII
  ubiquinol-cytochrome c reductase core protein 1
  ubiquinol-cytochrome c reductase core protein 2
  ubiquitin specific peptidase 13
  unk zinc finger
  vir like m6A methyltransferase associated
  voltage dependent anion channel 1
  voltage dependent anion channel 2
  Yes1 associated transcriptional regulator
  zinc finger protein 782

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.