SUCLG1, succinate-CoA ligase GDP/ADP-forming subunit alpha

SUCLG1, succinate-CoA ligase GDP/ADP-forming subunit alpha

• This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]

• Gene Synonyms (succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial, SCS-alpha, succinate-CoA ligase alpha subunit, succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial, succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial, succinyl-CoA synthetase subunit alpha, GALPHA, MTDPS9, SUCLA1,)
• NCBI Gene ID: 8802
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P53597
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

succinate-CoA ligase GDP/ADP-forming subunit alpha interacts with:

• 5'-nucleotidase, cytosolic IIIA
  abhydrolase domain containing 10, depalmitoylase
  acid phosphatase 6, lysophosphatidic
  acyl-CoA synthetase family member 2
  alanyl-tRNA synthetase 2, mitochondrial
  apoptosis inducing factor mitochondria associated 1
  BCL2 like 14
  charged multivesicular body protein 1B
  copper chaperone for superoxide dismutase
  cytidine/uridine monophosphate kinase 1
  dedicator of cytokinesis 10
  egl-9 family hypoxia inducible factor 3
  ETHE1 persulfide dioxygenase
  ferredoxin 2
  glutathione S-transferase omega 1
  GrpE like 1, mitochondrial
  guanine monophosphate synthase
  histone deacetylase 4
  interferon induced transmembrane protein 3
  leucyl-tRNA synthetase 2, mitochondrial
  mitochondrial rRNA methyltransferase 1
  NAD(P)HX epimerase
  NFU1 iron-sulfur cluster scaffold
  nipsnap homolog 3A
  nitrilase family member 2
  peptidase, mitochondrial processing subunit alpha
  peptidase, mitochondrial processing subunit beta
  pitrilysin metallopeptidase 1
  pleckstrin homology domain containing A4
  protein O-glucosyltransferase 3
  replication timing regulatory factor 1
  RNA exonuclease 2
  RNA polymerase III subunit C
  S100 calcium binding protein A16
  selenium binding protein 1
  septin 11
  septin 9
  SET domain bifurcated histone lysine methyltransferase 1
  SH3 domain binding glutamate rich protein like 3
  succinate-CoA ligase ADP-forming subunit beta
  tripartite motif containing 14
  tripartite motif containing 28
  tRNA methyltransferase 61B
  tubulin, gamma 1
  tyrosyl-tRNA synthetase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.