PCNT, pericentrin

PCNT, pericentrin

• The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

• Gene Synonyms (KEN, MOPD2, PCN, PCNT2, PCNTB, PCTN2, SCKL4, pericentrin, kendrin, pericentrin-2, pericentrin-380, pericentrin-B,)
• NCBI Gene ID: 5116
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95613
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

pericentrin interacts with:

• A-kinase anchoring protein 9
  baculoviral IAP repeat containing 7
  bromodomain containing 7
  CDK5 regulatory subunit associated protein 2
  CDK5 regulatory subunit associated protein 2
  centriolin
  centromere protein J
  centrosomal protein 120
  centrosomal protein 131
  centrosomal protein 152
  centrosomal protein 162
  centrosomal protein 192
  centrosomal protein 290
  centrosomal protein 43
  centrosomal protein 55
  centrosomal protein 63
  centrosomal protein 68
  centrosomal protein 72
  chromosome 1 open reading frame 87
  chromosome 7 open reading frame 50
  coiled-coil domain containing 183
  coiled-coil domain containing 8
  decapping enzyme, scavenger
  deuterosome assembly protein 1
  DISC1 scaffold protein
  dynein cytoplasmic 1 light intermediate chain 1
  dystrobrevin binding protein 1
  EP300 interacting inhibitor of differentiation 1
  exocyst complex component 1
  family with sequence similarity 81 member B
  fibrinogen like 2
  gigaxonin
  IKBKB interacting protein
  IMP U3 small nucleolar ribonucleoprotein 4
  leupaxin
  mediator complex subunit 4
  metastasis associated 1 family member 2
  methyl-CpG binding domain protein 3
  microtubule associated protein RP/EB family member 1
  mindbomb E3 ubiquitin protein ligase 1
  MIS18 kinetochore protein A
  mitotic spindle organizing protein 1
  MPV17 mitochondrial inner membrane protein like 2
  ninein
  ninein like
  obscurin like cytoskeletal adaptor 1
  OFD1 centriole and centriolar satellite protein
  paraoxonase 2
  polo like kinase 4
  progesterone immunomodulatory binding factor 1
  proteasome 26S subunit, non-ATPase 14
  protein kinase cAMP-dependent type II regulatory subunit alpha
  protein kinase, cAMP dependent regulatory, type II alpha
  protein kinase, cAMP dependent, catalytic, beta
  Rac GTPase activating protein 1
  RB binding protein 7, chromatin remodeling factor
  RPGRIP1 like
  sequestosome 1
  SET domain containing 1A, histone lysine methyltransferase
  sirtuin 7
  SUZ12 polycomb repressive complex 2 subunit
  t-complex 10 like
  thioredoxin domain containing 11
  translin associated factor X
  transmembrane anterior posterior transformation 1
  transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
  tripartite motif containing 43
  tubulin gamma 1
  tubulin gamma complex associated protein 2
  tubulin gamma complex associated protein 3
  tumor protein p53 binding protein 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  vir like m6A methyltransferase associated
  WD repeat domain 35

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.