PADI3, peptidyl arginine deiminase 3

PADI3, peptidyl arginine deiminase 3

• This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

• Gene Synonyms (protein-arginine deiminase type-3, peptidyl arginine deiminase, type III, peptidylarginine deiminase III, protein-arginine deiminase type III, PAD3, PDI3, UHS1,)
• NCBI Gene ID: 51702
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9ULW8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

peptidyl arginine deiminase 3 interacts with:

• inhibitor of CDK, cyclin A1 interacting protein 1
  interleukin 31 receptor A
  microtubule associated protein 1 light chain 3 alpha
  mitochondrial ribosomal protein L38
  peptidyl arginine deiminase 3
  pyrin and HIN domain family member 1
  shugoshin 2
  testis expressed 35

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