USP35, ubiquitin specific peptidase 35

USP35, ubiquitin specific peptidase 35

• This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]

• Gene Synonyms (ubiquitin carboxyl-terminal hydrolase 35, deubiquitinating enzyme 35, ubiquitin specific protease 35, ubiquitin thioesterase 35, ubiquitin thiolesterase 35, ubiquitin-specific-processing protease 35,)
• NCBI Gene ID: 57558
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9P2H5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin specific peptidase 35 interacts with:

• SMAD specific E3 ubiquitin protein ligase 2
  stimulator of interferon response cGAMP interactor 1
  TNFAIP3 interacting protein 2
  ubiquitin specific peptidase 35

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.