SDHC, succinate dehydrogenase complex subunit C

SDHC, succinate dehydrogenase complex subunit C

• This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]

• Gene Synonyms (succinate dehydrogenase cytochrome b560 subunit, mitochondrial, cytochrome B large subunit of complex II, integral membrane protein CII-3b, large subunit of cytochrome b, succinate dehydrgenase cytochrome b, succinate dehydrogenase 3, integral membrane subunit, succinate dehydrogenase complex subunit C integral membrane protein 15kDa, succinate dehydrogenase complex, subunit C, integral membrane protein, 15kD, succinate-ubiquinone oxidoreductase cytochrome B large subunit, CYB560, CYBL, PGL3, QPS1, SDH3,)
• NCBI Gene ID: 6391
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z4C9
  UNIPROT ID#>>A0A0S2Z4B7
  UNIPROT ID#>>Q99643
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

succinate dehydrogenase complex subunit C interacts with:

• anaphase promoting complex subunit 13
  catenin beta like 1
  cysteinyl-tRNA synthetase 2, mitochondrial
  distal membrane arm assembly complex 1
  Fas binding factor 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  mitochondrial carrier 2
  OFD1 centriole and centriolar satellite protein
  pentatricopeptide repeat domain 1
  POC5 centriolar protein
  small nuclear RNA activating complex polypeptide 1
  succinate dehydrogenase complex subunit C
  ubiquitin like modifier activating enzyme 2
  unk zinc finger
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.