CENPH, centromere protein H

CENPH, centromere protein H

• Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]

• Gene Synonyms (centromere protein H, CENP-H, interphase centromere complex protein 35, kinetochore protein CENP-H,)
• NCBI Gene ID: 64946
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z5T0
  UNIPROT ID#>>Q9H3R5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

centromere protein H interacts with:

• centromere protein H
  centromere protein I
  centromere protein O
  centromere protein P
  centromere protein S
  centromere protein U
  chromosome 1 open reading frame 216
  chromosome 8 open reading frame 58
  coiled-coil domain containing 107
  coiled-coil domain containing 151
  intraflagellar transport 20
  NUF2 component of NDC80 kinetochore complex
  Ras association domain family member 4
  sodium channel and clathrin linker 1
  SSX family member 2 interacting protein
  synaptonemal complex central element protein 3
  zinc finger protein 493

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