STX1A, syntaxin 1A

STX1A, syntaxin 1A

• This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

• Gene Synonyms (syntaxin-1A, neuron-specific antigen HPC-1, syntaxin 1A (brain), HPC-1, P35-1, STX1, SYN1A,)
• NCBI Gene ID: 6804
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q16623
  UNIPROT ID#>>Q75ME0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

syntaxin 1A interacts with:

• ABI family member 3
  ADP ribosylation factor like GTPase 13B
  alanine and arginine rich domain containing protein
  amine oxidase copper containing 3
  androgen induced 1
  angiotensin II receptor associated protein
  ankyrin repeat domain 46
  apolipoprotein L2
  apolipoprotein L3
  ATP binding cassette subfamily C member 9
  Bet1 golgi vesicular membrane trafficking protein
  biogenesis of lysosomal organelles complex 1 subunit 6
  butyrophilin subfamily 2 member A2
  cell division cycle 37, HSP90 cochaperone
  chromosome 4 open reading frame 3
  CKLF like MARVEL transmembrane domain containing 7
  CLN6 transmembrane ER protein
  coiled-coil serine rich protein 2
  complexin 1
  complexin 2
  core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
  C-type lectin domain family 1 member A
  C-X-C motif chemokine ligand 16
  cytochrome b5 type B
  DEAD-box helicase 49
  dynein axonemal assembly factor 2
  ergosterol biosynthesis 28 homolog
  estrogen receptor binding site associated antigen 9
  ethanolamine kinase 2
  FAM3 metabolism regulating signaling molecule C
  golgi membrane protein 2
  golgi SNAP receptor complex member 2
  GTPase, IMAP family member 1
  GTPase, IMAP family member 5
  HCLS1 associated protein X-1
  huntingtin
  jagunal homolog 1
  mal, T cell differentiation protein like
  membrane magnesium transporter 1
  NSF attachment protein alpha
  NSF attachment protein beta
  nuclear FMR1 interacting protein 1
  nurim
  Opa interacting protein 5
  phospholipid phosphatase 4
  phospholipid phosphatase 6
  post-GPI attachment to proteins 2
  receptor transporter protein 2
  regulating synaptic membrane exocytosis 1
  regulator of microtubule dynamics 2
  ring finger protein 40
  SEC22 homolog A, vesicle trafficking protein
  SEC22 homolog B, vesicle trafficking protein
  secondary ossification center associated regulator of chondrocyte maturation
  small integral membrane protein 1 (Vel blood group)
  small integral membrane protein 3
  small transmembrane regulator of ion transport 1
  solute carrier family 6 member 5
  stress associated endoplasmic reticulum protein 1
  stress associated endoplasmic reticulum protein family member 2
  synaptophysin
  synaptosomal-associated protein 23
  synaptosome associated protein 23
  synaptosome associated protein 29
  synaptosome associated protein 47
  synaptotagmin 1
  synaptotagmin 4
  synaptotagmin 7
  synaptotagmin like 4
  syntaphilin
  syntaxin 10
  syntaxin 11
  syntaxin 12
  syntaxin 16
  syntaxin 1A
  syntaxin 3
  syntaxin 4
  syntaxin 5
  syntaxin 6
  syntaxin 7
  syntaxin 8
  syntaxin binding protein 1
  syntaxin binding protein 2
  syntaxin binding protein 5
  syntaxin binding protein 6
  taxilin alpha
  taxilin beta
  testis specific 10 interacting protein
  TNFAIP3 interacting protein 2
  TRAF3 interacting protein 3
  transcription elongation factor A N-terminal and central domain containing
  transmembrane protein 100
  transmembrane protein 120A
  transmembrane protein 128
  transmembrane protein 14C
  transmembrane protein 199
  transmembrane protein 222
  transmembrane protein 254
  transmembrane protein 41A
  transmembrane protein 60
  t-SNARE domain containing 1
  tumor necrosis factor
  ubiquitin conjugating enzyme E2 I
  unc-13 homolog B
  unconventional SNARE in the ER 1
  upstream binding transcription factor like 1
  uroplakin 1B
  VAMP associated protein B and C
  vesicle associated membrane protein 1
  vesicle associated membrane protein 2
  vesicle associated membrane protein 3
  vesicle associated membrane protein 4
  vesicle associated membrane protein 5
  vesicle associated membrane protein 7
  vesicle associated membrane protein 8
  vesicle transport through interaction with t-SNAREs 1B
  vimentin
  VPS11 core subunit of CORVET and HOPS complexes
  VPS16 core subunit of CORVET and HOPS complexes
  VPS18 core subunit of CORVET and HOPS complexes
  V-set and transmembrane domain containing 4
  zinc finger protein 12
  zinc finger protein 136
  zinc finger protein 250
  zinc finger protein 440
  zinc finger protein 441
  zinc finger protein 479
  zinc finger protein 490
  zinc finger protein 557
  zinc finger protein 696
  zinc finger protein 707
  zinc finger protein 785
  zinc finger protein 835
  zinc finger protein like 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.