USP5, ubiquitin specific peptidase 5

USP5, ubiquitin specific peptidase 5

• Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]

• Gene Synonyms (ubiquitin carboxyl-terminal hydrolase 5, deubiquitinating enzyme 5, isopeptidase T, testicular tissue protein Li 218, ubiquitin isopeptidase T, ubiquitin specific protease 5 (isopeptidase T), ubiquitin thioesterase 5, ubiquitin thiolesterase 5, ubiquitin-specific protease-5 (ubiquitin isopeptidase T), ubiquitin-specific-processing protease 5, ISOT,)
• NCBI Gene ID: 8078
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A140VJZ1
  UNIPROT ID#>>P45974
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin specific peptidase 5 interacts with:

• 5'-nucleotidase, cytosolic II
  AAR2 splicing factor
  anterior gradient 2, protein disulphide isomerase family member
  autophagy related 16 like 1
  BCL2 like 14
  calcium voltage-gated channel subunit alpha1 H
  centrosomal protein 19
  cullin 7
  DAZ associated protein 2
  dual specificity phosphatase 19
  dual specificity phosphatase 22
  elongation factor Tu GTP binding domain containing 2
  G3BP stress granule assembly factor 1
  glucosamine-6-phosphate deaminase 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 4
  importin 9
  itchy E3 ubiquitin protein ligase
  L antigen family member 3
  limb development membrane protein 1 like
  lysine demethylase 5C
  MAF bZIP transcription factor B
  MCTS1 re-initiation and release factor
  nuclear RNA export factor 1
  OTU deubiquitinase with linear linkage specificity
  oxidative stress responsive kinase 1
  oxysterol binding protein like 8
  PDZ binding kinase
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  praja ring finger ubiquitin ligase 1
  progesterone receptor membrane component 1
  RAD18 E3 ubiquitin protein ligase
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  ring finger protein 11
  ring finger protein 216
  serine/threonine kinase 33
  sirtuin 7
  SMAD specific E3 ubiquitin protein ligase 1
  spartin
  STIP1 homology and U-box containing protein 1
  thiamine triphosphatase
  thioredoxin domain containing 17
  thioredoxin like 1
  transcription elongation factor A like 4
  transcriptional adaptor 3
  transmembrane protein 239
  tripartite motif containing 39
  tripartite motif containing 5
  tripartite motif containing 54
  tripartite motif containing 55
  tripartite motif containing 63
  tripartite motif containing 8
  tripartite motif family like 1
  tRNA nucleotidyl transferase 1
  tropomodulin 3
  ubiquitin conjugating enzyme E2 S
  ubiquitin domain containing 2
  ubiquitin like modifier activating enzyme 5
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin related modifier 1
  ubiquitin specific peptidase 13
  ubiquitin specific peptidase 28
  WW domain containing E3 ubiquitin protein ligase 2
  YTH N6-methyladenosine RNA binding protein 1
  YTH N6-methyladenosine RNA binding protein 2
  ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
  zinc finger protein 593

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.