SIGLEC5, sialic acid binding Ig like lectin 5

SIGLEC5, sialic acid binding Ig like lectin 5

• This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]

• Gene Synonyms (sialic acid-binding Ig-like lectin 5, CD33 antigen-like 2, OB-binding protein 2, obesity-binding protein 2, sialic acid-binding immunoglobulin-like lectin 5, CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5,)
• NCBI Gene ID: 8778
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O15389
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sialic acid binding Ig like lectin 5 interacts with:

• eEF1A lysine and N-terminal methyltransferase
  GPN-loop GTPase 3
  integrator complex subunit 4
  kelch like family member 8
  NSF attachment protein beta
  phosphatase, orphan 2
  sialic acid binding Ig like lectin 5
  solute carrier family 7 member 8
  thyroid hormone receptor interactor 10
  thyroid hormone receptor interactor 13
  UFM1 specific peptidase 2
  VAC14 component of PIKFYVE complex

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.