DPM2, dolichyl-phosphate mannosyltransferase subunit 2, regulatory

DPM2, dolichyl-phosphate mannosyltransferase subunit 2, regulatory

• Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]

• Gene Synonyms (dolichol phosphate-mannose biosynthesis regulatory protein, DPM synthase complex subunit, DPM synthase subunit 2, dolichol-phosphate mannose synthase subunit 2, dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit, CDG1U,)
• NCBI Gene ID: 8818
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O94777
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dolichyl-phosphate mannosyltransferase subunit 2, regulatory interacts with:

• dolichyl-phosphate mannosyltransferase subunit 2, regulatory
  dolichyl-phosphate mannosyltransferase subunit 3, regulatory
  phosphatidylinositol glycan anchor biosynthesis class P
  vitamin K epoxide reductase complex subunit 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.