CDK5R1, cyclin dependent kinase 5 regulatory subunit 1

CDK5R1, cyclin dependent kinase 5 regulatory subunit 1

• The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

• Gene Synonyms (cyclin-dependent kinase 5 activator 1, CDK5 activator 1, TPKII regulatory subunit, neuronal CDK5 activator, regulatory partner for CDK5 kinase, tau protein kinase II 23kDa subunit, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a,)
• NCBI Gene ID: 8851
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15078
  UNIPROT ID#>>Q8N619
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

cyclin dependent kinase 5 regulatory subunit 1 interacts with:

• apoptosis associated tyrosine kinase
  biogenesis of lysosomal organelles complex 1 subunit 6
  CDK5 regulatory subunit associated protein 1
  CDK5 regulatory subunit associated protein 2
  CDK5 regulatory subunit associated protein 3
  cyclin dependent kinase 5 regulatory subunit 1
  keratin 40
  keratin associated protein 10-3
  lemur tyrosine kinase 2
  metabolism of cobalamin associated B
  microtubule associated scaffold protein 2
  multivesicular body subunit 12A
  nestin
  notch 2 N-terminal like A
  pyridoxal phosphate binding protein
  ring finger and SPRY domain containing 1
  suppressor of defective silencing 3 homolog (S. cerevisiae)
  tau tubulin kinase 1
  TNFAIP3 interacting protein 2
  TSC22 domain family member 4
  ubiquitin conjugating enzyme E2 T
  UBX domain protein 1
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.