FYN, FYN proto-oncogene, Src family tyrosine kinase

FYN, FYN proto-oncogene, Src family tyrosine kinase

• This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

• Gene Synonyms (SLK, SYN, p59-FYN, tyrosine-protein kinase Fyn, FYN oncogene related to SRC, FGR, YES, OKT3-induced calcium influx regulator, c-syn protooncogene, proto-oncogene Syn, proto-oncogene c-Fyn, src-like kinase, src/yes-related novel, tyrosine kinase p59fyn(T),)
• NCBI Gene ID: 2534
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P06241
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

FYN proto-oncogene, Src family tyrosine kinase interacts with:

• 5-hydroxytryptamine receptor 6
  acyl-CoA binding domain containing 7
  ADAM metallopeptidase domain 15
  anillin actin binding protein
  ankyrin repeat domain 12
  ataxin 1
  ATP binding cassette subfamily E member 1
  BAG cochaperone 4
  BCAR1 scaffold protein, Cas family member
  Bet1 golgi vesicular membrane trafficking protein
  Cbl proto-oncogene C
  CD2 associated protein
  CD226 molecule
  CD244 molecule
  cell division cycle 37, HSP90 cochaperone
  chromosome 7 open reading frame 25
  chromosome 8 open reading frame 33
  coiled-coil domain containing 8
  contactin associated protein 1
  coronin, actin binding protein 1C
  cyclin L2
  deltex E3 ubiquitin ligase 3
  DLG associated protein 4
  docking protein 2
  docking protein 3
  docking protein 4
  embryonal Fyn-associated substrate
  embryonal Fyn-associated substrate
  Enah/Vasp-like
  ERBB receptor feedback inhibitor 1
  family with sequence similarity 90 member A1
  filamin, beta
  flotillin 1
  formin binding protein 4
  FYN proto-oncogene, Src family tyrosine kinase
  G protein subunit beta 1
  G protein subunit gamma 2
  gap junction protein beta 7
  glutamate ionotropic receptor NMDA type subunit 1
  glutamate ionotropic receptor NMDA type subunit 2A
  glutamate ionotropic receptor NMDA type subunit 2B
  glutamate metabotropic receptor 1
  glycoprotein VI platelet
  GRB2 associated binding protein 3
  GRB2 related adaptor protein
  growth factor receptor bound protein 10
  growth factor receptor bound protein 2
  heat shock protein 90 alpha family class A member 1
  heat shock protein 90 alpha family class B member 1
  hepatitis A virus cellular receptor 1
  heterogeneous nuclear ribonucleoprotein K
  HEXIM P-TEFb complex subunit 1
  homeobox B5
  HRas proto-oncogene, GTPase
  IL2 inducible T cell kinase
  inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
  inositol 1,4,5-trisphosphate receptor type 1
  insulin receptor substrate 1
  integrin subunit beta 4
  interferon induced transmembrane protein 3
  interleukin 1 beta
  interleukin 2 receptor subunit beta
  interleukin 7 receptor
  itchy E3 ubiquitin protein ligase
  Janus kinase 2
  junction plakoglobin
  kalirin RhoGEF kinase
  KH RNA binding domain containing, signal transduction associated 1
  kinase insert domain receptor
  KIT proto-oncogene, receptor tyrosine kinase
  La ribonucleoprotein 7, transcriptional regulator
  LCK proto-oncogene, Src family tyrosine kinase
  leucine rich repeats and IQ motif containing 1
  LIM domain kinase 1
  linker for activation of T cells
  lymphocyte cytosolic protein 2
  lysine demethylase 1A
  mediator complex subunit 21
  mediator complex subunit 28
  melanoma cell adhesion molecule
  mesenchyme homeobox 2
  metastasis associated 1
  metastasis associated 3
  metaxin 1
  microtubule associated protein 2
  microtubule associated protein RP/EB family member 1
  microtubule associated protein tau
  microtubule associated scaffold protein 2
  myelin associated glycoprotein
  myelin basic protein
  myosin heavy chain 9
  myosin XVIIIA
  myosin, heavy polypeptide 9, non-muscle
  NEDD4 E3 ubiquitin protein ligase
  Nedd4 family interacting protein 2
  neural cell adhesion molecule 1
  neural precursor cell expressed, developmentally down-regulated 9
  neurotrophic receptor tyrosine kinase 2
  nitric oxide synthase 1 adaptor protein
  N-myristoyltransferase 1
  NPHS1 adhesion molecule, nephrin
  nuclear receptor subfamily 3 group C member 1
  O-sialoglycoprotein endopeptidase
  p21 (RAC1) activated kinase 2
  paxillin
  phosphodiesterase 4D
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  phosphoinositide-3-kinase regulatory subunit 3
  phospholipase C gamma 1
  phospholipase C gamma 2
  phospholipase D2
  phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  plasminogen activator, urokinase receptor
  platelet and endothelial cell adhesion molecule 1
  platelet derived growth factor receptor beta
  pleckstrin homology domain containing A4
  PMS1 homolog 2, mismatch repair system component
  potassium voltage-gated channel subfamily A member 2
  potassium voltage-gated channel subfamily A member 4
  potassium voltage-gated channel subfamily A member 5
  protein arginine methyltransferase 6
  protein kinase C delta
  protein kinase C epsilon
  protein kinase C eta
  protein kinase C iota
  protein kinase C theta
  protein kinase C zeta
  protein tyrosine kinase 2
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 5
  protein tyrosine phosphatase receptor type A
  protein tyrosine phosphatase receptor type C
  protein tyrosine phosphatase receptor type D
  protein tyrosine phosphatase receptor type E
  protein tyrosine phosphatase receptor type F
  protein tyrosine phosphatase receptor type Z1
  protocadherin gamma subfamily C, 3
  prune homolog 2 with BCH domain
  Raf-1 proto-oncogene, serine/threonine kinase
  receptor for activated C kinase 1
  Rho GTPase activating protein 32
  Rho GTPase activating protein 33
  ribosomal protein L10
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A2
  ribosomal protein S6 kinase A3
  ribosomal protein S6 kinase B2
  SH2 domain containing 1A
  SH2B adaptor protein 2
  SH3 domain binding protein 2
  SH3 domain containing kinase binding protein 1
  SHC adaptor protein 1
  sialophorin
  signal transducer and activator of transcription 1
  signal transducer and activator of transcription 3
  signaling lymphocytic activation molecule family member 1
  signaling threshold regulating transmembrane adaptor 1
  solute carrier family 25 member 11
  solute carrier family 25 member 41
  solute carrier family 4 member 8
  SOS Ras/Rac guanine nucleotide exchange factor 1
  sphingosine kinase 1
  sphingosine kinase 2
  spleen associated tyrosine kinase
  src kinase associated phosphoprotein 1
  src kinase associated phosphoprotein 2
  SRC proto-oncogene, non-receptor tyrosine kinase
  superoxide dismutase 1, soluble
  suppressor of cytokine signaling 1
  suppressor of variegation 3-9 homolog 1
  syndecan 1
  syndecan 3
  synuclein alpha
  T cell receptor associated transmembrane adaptor 1
  target of myb1 like 1 membrane trafficking protein
  Thy-1 cell surface antigen
  titin-cap
  TNF receptor associated factor 6
  TNF receptor superfamily member 10b
  TNF receptor superfamily member 1A
  trafficking regulator and scaffold protein tamalin
  transient receptor potential cation channel subfamily C member 6
  transient receptor potential cation channel subfamily V member 4
  translin associated factor X
  transmembrane protein 132A
  transmembrane protein 185A
  tripartite motif-containing 69
  troponin T1, slow skeletal type
  tubulin alpha 1b
  tubulin alpha 3c
  tubulin alpha 4a
  tumor necrosis factor
  TXK tyrosine kinase
  TYRO3 protein tyrosine kinase
  tyrosine kinase 2
  tyrosine kinase non receptor 2
  ubiquitin like with PHD and ring finger domains 2
  unc-119 lipid binding chaperone
  vav guanine nucleotide exchange factor 1
  vav guanine nucleotide exchange factor 2
  WASP actin nucleation promoting factor
  WASP family member 1
  WASP family member 2
  WW domain binding protein 11
  YES proto-oncogene 1, Src family tyrosine kinase
  YTH domain containing 1
  zeta chain of T cell receptor associated protein kinase 70
  zinc finger NFX1-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.