GHR, growth hormone receptor

GHR, growth hormone receptor

• This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

• Gene Synonyms (GHBP, GHIP, growth hormone receptor, GH receptor, growth hormone binding protein, serum binding protein, somatotropin receptor,)
• NCBI Gene ID: 2690
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A087X0H5
  UNIPROT ID#>>P10912
  UNIPROT ID#>>A0A087X162
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

growth hormone receptor interacts with:

• beta-transducin repeat containing E3 ubiquitin protein ligase
  cullin 1
  cullin 5
  elongin B
  elongin C
  F-box and WD repeat domain containing 11
  F-box protein 31
  growth factor receptor bound protein 10
  growth factor receptor bound protein 2
  growth hormone receptor
  insulin like growth factor 1 receptor
  insulin receptor substrate 1
  Janus kinase 1
  Janus kinase 2
  NCK adaptor protein 1
  NEDD8 ubiquitin like modifier
  nuclear receptor coactivator 6
  phosphoinositide-3-kinase regulatory subunit 1
  phosphoinositide-3-kinase regulatory subunit 2
  phospholipase C gamma 1
  prolactin receptor
  protein tyrosine phosphatase non-receptor type 1
  protein tyrosine phosphatase non-receptor type 11
  protein tyrosine phosphatase non-receptor type 13
  protein tyrosine phosphatase non-receptor type 2
  protein tyrosine phosphatase non-receptor type 3
  protein tyrosine phosphatase non-receptor type 6
  protein tyrosine phosphatase non-receptor type 9
  protein tyrosine phosphatase receptor type B
  protein tyrosine phosphatase receptor type H
  ring finger protein 7
  ring-box 1
  SHC adaptor protein 1
  signal transducer and activator of transcription 3
  signal transducer and activator of transcription 5A
  signal transducer and activator of transcription 5B
  small glutamine rich tetratricopeptide repeat containing alpha
  S-phase kinase associated protein 1
  SRSF protein kinase 2
  STIP1 homology and U-box containing protein 1
  suppressor of cytokine signaling 1
  suppressor of cytokine signaling 2
  suppressor of cytokine signaling 3
  tyrosine kinase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.