PTPN3, protein tyrosine phosphatase non-receptor type 3

PTPN3, protein tyrosine phosphatase non-receptor type 3

• The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

• Gene Synonyms (tyrosine-protein phosphatase non-receptor type 3, cytoskeletal-associated protein tyrosine phosphatase, protein-tyrosine phosphatase H1, PTP-H1, PTPH1,)
• NCBI Gene ID: 5774
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7ZA03
  UNIPROT ID#>>Q8N4S3
  UNIPROT ID#>>B7Z9V1
  UNIPROT ID#>>B7Z3V3
  UNIPROT ID#>>P26045
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein tyrosine phosphatase non-receptor type 3 interacts with:

• 6-phosphogluconolactonase
  acyl-CoA thioesterase 8
  ADAM metallopeptidase domain 17
  adenosylhomocysteinase like 1
  ankyrin repeat domain 50
  asparagine synthetase domain containing 1
  calcyclin binding protein
  denticleless E3 ubiquitin protein ligase homolog
  diacylglycerol kinase zeta
  disco interacting protein 2 homolog A
  DLG associated protein 3
  erythrocyte membrane protein band 4.1 like 5
  eukaryotic translation initiation factor 3 subunit A
  eukaryotic translation initiation factor 3 subunit B
  exophilin 5
  HEAT repeat containing 5B
  kinase D interacting substrate 220
  kinesin family member 2C
  KN motif and ankyrin repeat domains 2
  leucine rich pentatricopeptide repeat containing
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S27
  mitochondrial ribosomal protein S35
  mitochondrial ribosomal protein S7
  mitogen-activated protein kinase 12
  myogenesis regulating glycosidase (putative)
  myotubularin related protein 9
  nuclear transport factor 2 like export factor 2
  pentatricopeptide repeat domain 3
  pleckstrin homology and FYVE domain containing 2
  potassium channel tetramerization domain containing 3
  protein kinase D2
  protein tyrosine phosphatase non-receptor type 3
  ribosomal protein S17
  ribosomal protein S6 kinase A1
  ribosomal protein S6 kinase A3
  ring finger protein 111
  Scm polycomb group protein like 1
  serine/arginine repetitive matrix 2
  SH3KBP1 binding protein 1
  solute carrier family 1 member 5
  succinate dehydrogenase complex flavoprotein subunit A
  terminal nucleotidyltransferase 5D
  tight junction protein 1
  tight junction protein 2
  transcription factor AP-4
  tripartite motif containing 25
  tripartite motif containing 41
  tRNA splicing endonuclease subunit 34
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin conjugating enzyme E2 O
  ubiquitin protein ligase E3A
  valosin containing protein
  VANGL planar cell polarity protein 1
  VANGL planar cell polarity protein 2
  vir like m6A methyltransferase associated
  vitamin D receptor
  von Willebrand factor A domain containing 2
  WD repeat domain 6
  WD repeat domain 70
  xenotropic and polytropic retrovirus receptor 1
  zeta chain of T cell receptor associated protein kinase 70
  zinc finger CCHC-type containing 10

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.