MTF1, metal regulatory transcription factor 1

MTF1, metal regulatory transcription factor 1

• This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]

• Gene Synonyms (MTF-1, ZRF, metal regulatory transcription factor 1, MRE-binding transcription factor, MRE-binding transcription factor-1, metal-responsive transcription factor 1, transcription factor MTF-1, zinc regulatory factor,)
• NCBI Gene ID: 4520
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q14872
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

metal regulatory transcription factor 1 interacts with:

• adaptor related protein complex 1 subunit mu 1
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  DDB1 and CUL4 associated factor 13
  DEAD-box helicase 17
  DEAD-box helicase 18
  DEAD-box helicase 27
  DEAD-box helicase 3 Y-linked
  developmentally regulated GTP binding protein 1
  DExD-box helicase 21
  DExH-box helicase 30
  DnaJ heat shock protein family (Hsp40) member C2
  elongation factor Tu GTP binding domain containing 2
  exosome component 10
  G protein nucleolar 3
  GTP binding protein 4
  H4 clustered histone 1
  heat shock protein family A (Hsp70) member 14
  heterogeneous nuclear ribonucleoprotein A1 like 2
  heterogeneous nuclear ribonucleoprotein M
  insulin like growth factor 2 mRNA binding protein 1
  matrin 3
  MYB binding protein 1a
  N-acetyltransferase 10
  NFKB repressing factor
  NOC2 like nucleolar associated transcriptional repressor
  non-POU domain containing octamer binding
  NOP2 nucleolar protein
  NOP56 ribonucleoprotein
  nucleolin
  nucleophosmin 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 8
  programmed cell death 11
  prohibitin 2
  protein arginine methyltransferase 5
  protein kinase, DNA-activated, catalytic subunit
  RBMX like 1
  ribosomal L1 domain containing 1
  ribosomal protein L10
  ribosomal protein L10a
  ribosomal protein L11
  ribosomal protein L14
  ribosomal protein L15
  ribosomal protein L18a
  ribosomal protein L19
  ribosomal protein L23a
  ribosomal protein L27
  ribosomal protein L28
  ribosomal protein L3
  ribosomal protein L35a
  ribosomal protein L4
  ribosomal protein L5
  ribosomal protein L7
  ribosomal protein L7a
  ribosomal protein L8
  ribosomal protein lateral stalk subunit P0
  ribosomal protein S11
  ribosomal protein S13
  ribosomal protein S16
  ribosomal protein S18
  ribosomal protein S19
  ribosomal protein S3
  ribosomal protein S3A
  ribosomal protein S4 X-linked
  ribosomal protein S6
  ribosomal protein S7
  ribosomal protein S8
  ribosomal protein S9
  ribosomal RNA processing 1B
  RNA binding motif protein 10
  RNA binding motif protein 28
  RNA binding motif protein X-linked
  serine and arginine rich splicing factor 1
  small nuclear ribonucleoprotein U5 subunit 200
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  SPT16 homolog, facilitates chromatin remodeling subunit
  structural maintenance of chromosomes 1A
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
  UDP-glucose glycoprotein glucosyltransferase 1
  vimentin
  vir like m6A methyltransferase associated
  XPC complex subunit, DNA damage recognition and repair factor
  X-ray repair cross complementing 5
  zinc finger CCCH-type containing 15

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.