TAF1, TATA-box binding protein associated factor 1

TAF1, TATA-box binding protein associated factor 1

• Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]

• Gene Synonyms (transcription initiation factor TFIID subunit 1, TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa, TBP-associated factor 250 kDa, cell cycle gene 1 protein, cell cycle, G1 phase defect, complementation of cell cycle block, G1-to-S, transcription factor TFIID p250 polypeptide, BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, MRXS33, N-TAF1, NSCL2, OF, P250, TAF(II)250, TAF2A, TAFII-250, TAFII250, XDP,)
• NCBI Gene ID: 6872
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P21675
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TATA-box binding protein associated factor 1 interacts with:

• anti-silencing function 1A histone chaperone
  anti-silencing function 1B histone chaperone
  brain expressed X-linked 2
  BRMS1 transcriptional repressor and anoikis regulator
  charged multivesicular body protein 4B
  cullin 3
  endothelial differentiation related factor 1
  eukaryotic translation initiation factor 3 subunit H
  GAR1 ribonucleoprotein
  general transcription factor IIIC, polypeptide 4
  growth factor independent 1B transcriptional repressor
  H3 clustered histone 1
  H3.4 histone
  H4 clustered histone 1
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT domain E3 ubiquitin protein ligase 1
  kinesin associated protein 3
  kinesin family binding protein
  LIM domain binding 1
  mediator complex subunit 26
  nuclear RNA export factor 1
  PHD finger protein 8
  saccharopine dehydrogenase (putative)
  septin 6
  SIN3 transcription regulator family member A
  structural maintenance of chromosomes 3
  SUB1 regulator of transcription
  TATA-box binding protein
  TATA-box binding protein associated factor 1
  TATA-box binding protein associated factor 10
  TATA-box binding protein associated factor 11
  TATA-box binding protein associated factor 12
  TATA-box binding protein associated factor 13
  TATA-box binding protein associated factor 15
  TATA-box binding protein associated factor 2
  TATA-box binding protein associated factor 3
  TATA-box binding protein associated factor 4
  TATA-box binding protein associated factor 4b
  TATA-box binding protein associated factor 5
  TATA-box binding protein associated factor 6
  TATA-box binding protein associated factor 7
  TATA-box binding protein associated factor 7 like
  TATA-box binding protein associated factor 8
  TATA-box binding protein associated factor 9
  TATA-box binding protein associated factor 9b
  TATA-box binding protein like 1
  TERF1 interacting nuclear factor 2
  transformation related protein 53 binding protein 1
  transmembrane protein 248
  tumor protein p53
  ubiquitin conjugating enzyme E2 I
  ubiquitin specific peptidase 37
  upstream binding transcription factor
  vacuolar protein sorting 28
  vir like m6A methyltransferase associated
  WD repeat domain 76
  YTH domain containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.