GLRX3, glutaredoxin 3

GLRX3, glutaredoxin 3

• This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

• Gene Synonyms (GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3, glutaredoxin-3, PKC-interacting cousin of thioredoxin, PKC-theta-interacting protein, PKCq-interacting protein, glutaredoxin 4, testicular tissue protein Li 75, thioredoxin-like protein 2,)
• NCBI Gene ID: 10539
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O76003
  UNIPROT ID#>>A0A140VJK1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

glutaredoxin 3 interacts with:

• AAR2 splicing factor
  ADAMTS like 3
  ADAMTS like 4
  AHNAK nucleoprotein 2
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  anterior gradient 2, protein disulphide isomerase family member
  BCL2 like 14
  bolA family member 1
  bolA family member 2
  bolA family member 2B
  bolA family member 3
  cerebral endothelial cell adhesion molecule
  Coenzyme A synthase
  coiled-coil alpha-helical rod protein 1
  cytokine induced apoptosis inhibitor 1
  cytosolic iron-sulfur assembly component 2B
  defective in cullin neddylation 1 domain containing 1
  dynein axonemal assembly factor 1
  EF-hand domain family member D2
  EGF containing fibulin extracellular matrix protein 2
  egl-9 family hypoxia inducible factor 3
  family with sequence similarity 118 member A
  FRA10A associated CGG repeat 1
  G protein subunit gamma 13
  germ cell-less 1, spermatogenesis associated
  glutaredoxin 3
  hexosaminidase D
  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
  inositol-3-phosphate synthase 1
  interactor of HORMAD1 1
  iroquois homeobox 6
  kelch domain containing 9
  keratin associated protein 10-1
  keratin associated protein 10-11
  keratin associated protein 10-3
  keratin associated protein 10-5
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 12-3
  keratin associated protein 1-3
  keratin associated protein 13-1
  keratin associated protein 4-11
  keratin associated protein 4-12
  keratin associated protein 4-2
  keratin associated protein 4-4
  keratin associated protein 4-5
  keratin associated protein 4-7
  keratin associated protein 5-11
  keratin associated protein 5-3
  keratin associated protein 5-6
  keratin associated protein 9-2
  keratin associated protein 9-3
  keratin associated protein 9-8
  KH RNA binding domain containing, signal transduction associated 1
  killer cell lectin like receptor G2
  late cornified envelope 2D
  leucine rich repeats and immunoglobulin like domains 1
  ligand of numb-protein X 1
  ligand of numb-protein X 2
  methionyl aminopeptidase 1
  mitogen-activated protein kinase binding protein 1
  MMS19 homolog, cytosolic iron-sulfur assembly component
  monooxygenase DBH like 1
  MYG1 exonuclease
  NAD kinase
  N-alpha-acetyltransferase 40, NatD catalytic subunit
  notch 2 N-terminal like A
  olfactomedin 3
  O-sialoglycoprotein endopeptidase
  pleckstrin homology and RhoGEF domain containing G4B
  pleckstrin homology domain containing A4
  protein kinase D2
  REST corepressor 3
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  signaling receptor and transporter of retinol STRA6
  SRY-box transcription factor 7
  TBC1 domain family member 23
  testis expressed 101
  TP53 regulating kinase
  transmembrane protein 25
  tripartite motif containing 36
  tripartite motif containing 42
  zinc finger and BTB domain containing 44
  zinc finger protein 426
  zinc finger protein 490
  zinc finger protein 512B
  zinc finger protein 544
  zinc finger protein 774

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.