DHODH, dihydroorotate dehydrogenase (quinone)

DHODH, dihydroorotate dehydrogenase (quinone)

• The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]

• Gene Synonyms (dihydroorotate dehydrogenase (quinone), mitochondrial, dihydroorotate oxidase, human complement of yeast URA1, DHOdehase, POADS, URA1,)
• NCBI Gene ID: 1723
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q02127
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dihydroorotate dehydrogenase (quinone) interacts with:

• alpha tocopherol transfer protein
  anaphase promoting complex subunit 13
  catenin beta like 1
  cell division cycle 16
  FKBP prolyl isomerase 8
  GDP-mannose pyrophosphorylase B
  GINS complex subunit 4
  heterogeneous nuclear ribonucleoprotein M
  HUS1 checkpoint clamp component
  interleukin enhancer binding factor 3
  metallothionein 2A
  mitochondrial ribosomal protein L32
  NADH:ubiquinone oxidoreductase core subunit S8
  oxoglutarate dehydrogenase
  proteolipid protein 2
  ring finger protein 19B
  single stranded DNA binding protein 1
  succinate dehydrogenase complex flavoprotein subunit A
  TATA-box binding protein associated factor 2
  TIMELESS interacting protein
  transmembrane p24 trafficking protein 10
  ubiquilin 2
  VAC14 component of PIKFYVE complex

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.